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TXNRD1 and TXNIP
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
TXNRD1
TXNIP
Description
thioredoxin reductase 1
thioredoxin interacting protein
Image
GO Annotations
Cellular Component
Fibrillar Center
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Extracellular Exosome
Nucleus
Cytoplasm
Mitochondrial Intermembrane Space
Cytosol
Molecular Function
Thioredoxin-disulfide Reductase Activity
Protein Binding
Protein Disulfide Oxidoreductase Activity
Flavin Adenine Dinucleotide Binding
Enzyme Inhibitor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Mesoderm Formation
Selenium Compound Metabolic Process
Signal Transduction
Cell Population Proliferation
Nucleobase-containing Small Molecule Interconversion
Regulation Of Lipid Metabolic Process
Cellular Response To Oxidative Stress
Cell Redox Homeostasis
Cellular Oxidant Detoxification
Negative Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Cell Cycle
Response To Mechanical Stimulus
Response To Glucose
Protein Transport
Keratinocyte Differentiation
Response To Estradiol
Response To Progesterone
Regulation Of Cell Population Proliferation
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Catalytic Activity
Platelet-derived Growth Factor Receptor Signaling Pathway
Response To Calcium Ion
Negative Regulation Of Cell Division
Cellular Response To Tumor Cell
Pathways
PPARA activates gene expression
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
Metabolism of ingested MeSeO2H into MeSeH
Uptake and function of diphtheria toxin
TP53 Regulates Metabolic Genes
The NLRP3 inflammasome
The NLRP3 inflammasome
Regulation of FOXO transcriptional activity by acetylation
Purinergic signaling in leishmaniasis infection
Purinergic signaling in leishmaniasis infection
Drugs
Arsenic trioxide
NADPH
Flavin adenine dinucleotide
Spermidine
Fotemustine
Motexafin gadolinium
PX-12
Diseases
GWAS
Blood protein levels (
30072576
)
Emphysema annual change measurement in smokers (percent low attenuation area) (
31324189
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Toenail selenium levels (
25343990
)
Interacting Genes
11 interacting genes:
DMRTC2
ESR1
ESR2
GLRX2
LINC01554
POU2F1
POU2F2
PPP1R16A
THRA
TXNDC17
TXNIP
20 interacting genes:
DDIT4
ECD
FHL1
HDAC1
HDAC3
HSPB2
ITCH
KPNA2
MAPK1
NLGN3
PRKAA1
PTPN11
SCEL
SMURF2
TRAF6
TXN
TXNRD1
UBR5
ZBTB16
ZBTB32
Entrez ID
7296
10628
HPRD ID
03068
05964
Ensembl ID
ENSG00000198431
ENSG00000265972
Uniprot IDs
B7Z2S5
Q16881
Q9H3M7
PDB IDs
1W1C
2CFY
2J3N
2ZZ0
2ZZB
2ZZC
3QFA
3QFB
4GEI
4GEJ
4GFX
4LL1
4LL4
4ROF
4ROJ
5CQ2
5DF6
5DWS
5DZD
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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