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TRAF5 and HSD17B10
Data Source:
BioGRID
(two hybrid)
TRAF5
HSD17B10
Description
TNF receptor associated factor 5
hydroxysteroid 17-beta dehydrogenase 10
Image
No pdb structure
GO Annotations
Cellular Component
Centrosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Plasma Membrane Signaling Receptor Complex
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Plasma Membrane
Mitochondrial Ribonuclease P Complex
Mitochondrial Nucleoid
Molecular Function
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
TRNA Binding
RNA Binding
3-hydroxyacyl-CoA Dehydrogenase Activity
Protein Binding
Cholate 7-alpha-dehydrogenase Activity
Testosterone Dehydrogenase [NAD(P)] Activity
17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
Testosterone Dehydrogenase (NAD+) Activity
Androstan-3-alpha,17-beta-diol Dehydrogenase Activity
Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity
Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Biological Process
Apoptotic Process
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JNK Cascade
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein K63-linked Ubiquitination
Isoleucine Catabolic Process
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Bile Acid Biosynthetic Process
Mitochondrion Organization
C21-steroid Hormone Metabolic Process
Androgen Metabolic Process
Estrogen Metabolic Process
Branched-chain Amino Acid Catabolic Process
Protein Homotetramerization
Brexanolone Metabolic Process
Mitochondrial TRNA Methylation
Mitochondrial TRNA Processing
Mitochondrial TRNA 5'-end Processing
Mitochondrial TRNA 3'-end Processing
Pathways
tRNA processing in the mitochondrion
tRNA modification in the mitochondrion
Branched-chain amino acid catabolism
rRNA processing in the mitochondrion
Drugs
NADH
1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Omega-3-carboxylic acids
Diseases
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
Non-syndromic X-linked mental retardation
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
Household income (MTAG) (
31844048
)
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Interacting Genes
66 interacting genes:
BEX3
CAPNS1
CCDC184
CD27
CD40
CDC37
CIB3
COG7
COMMD3
DGKH
ENOX2
FAM9A
FBXO28
GAS8
GOLGA2
GORASP2
HOMER1
HSD17B10
HSF2BP
LMO4
LNX1
LTBR
MAP3K14
MAP3K5
MDM2
MEOX2
NMI
NTAQ1
NUMBL
ODF2
PIAS2
PIBF1
PICK1
PSMA1
RAD23A
RIPK1
RIPK2
RNF111
RNF4
SDCBP
SEC13
SERPINB9
SUMO1
TBK1
TDP2
THAP1
THAP7
TNFRSF11A
TNFRSF12A
TNFRSF13B
TNFRSF14
TNFRSF19
TNFRSF4
TNFRSF8
TRAF2
TRAF3
TRAF3IP2
TRAF6
TRIM27
TRIM37
TRIM8
UBC
USP7
YPEL5
ZFAND6
ZNF655
32 interacting genes:
ALDH3B1
ALDOA
APP
ATP5F1A
CDC42
CHD3
CPS1
CS
ETFDH
FAF1
GLUD1
GLUL
HADHA
HADHB
HMGCL
HMGCS2
HTRA2
MDH1
OGDH
PDHA1
PDHB
PDHX
PRKN
PTEN
PYGL
TOMM20
TOMM22
TOMM40
TRAF3IP2
TRAF5
TRAF6
UBE2D1
Entrez ID
7188
3028
HPRD ID
03834
02223
Ensembl ID
ENSG00000082512
ENSG00000072506
Uniprot IDs
O00463
A0A0S2Z410
Q99714
PDB IDs
1F67
1SO8
1U7T
2O23
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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