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BUB1B and TP73
Data Source:
BioGRID
(affinity chromatography technology, pull down)
BUB1B
TP73
Description
BUB1 mitotic checkpoint serine/threonine kinase B
tumor protein p73
Image
GO Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome Kinetochore
Condensed Chromosome Outer Kinetochore
Anaphase-promoting Complex
Cytoplasm
Microtubule Organizing Center
Spindle
Cytosol
Perinuclear Region Of Cytoplasm
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cell Junction
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Identical Protein Binding
Metal Ion Binding
MDM2/MDM4 Family Protein Binding
Biological Process
Mitotic Cell Cycle
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Checkpoint
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Catabolic Process
Cell Division
Meiotic Sister Chromatid Cohesion, Centromeric
Protein Localization To Chromosome, Centromeric Region
Regulation Of Mitotic Cell Cycle Phase Transition
Activation Of MAPK Activity
Kidney Development
Mismatch Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Regulation Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Organonitrogen Compound
Regulation Of Gene Expression
Viral Process
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Protein Tetramerization
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Hepatocellular carcinoma
GWAS
Chronic lymphocytic leukemia (
28165464
24292274
)
Joint damage in rheumatoid arthritis (
31596875
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Visceral fat (
22589738
)
Waist-hip ratio (
28552196
)
Interacting Genes
26 interacting genes:
ANAPC7
AP1B1
AP2B1
AP3B1
AP4B1
APC
BRCA2
BUB3
CCNA2
CDC16
CDC20
CDC27
CENPE
COMMD4
DNMBP
FBXO7
FZR1
HDAC1
KNL1
MAP3K4
PELI1
PLK1
RIPK3
SNCG
TP73
TRIP13
63 interacting genes:
ABL1
ATF3
AURKA
BIN1
BUB1B
CABLES1
CCNB1
CCND1
CCNE1
CDK1
CDK2
CEBPZ
CHD3
CREBBP
CSNK2A1
DAXX
DDB1
EP300
FBXO45
FLNA
HCK
HECW2
HIPK2
HIPK3
HMGB1
HRAS
IKBKB
ITCH
KAT2B
MAPK8
MDM2
MDM4
MUL1
MYC
NEDD4
NFYB
PFDN5
PIAS1
PIN1
PLK1
PML
PPP1R13B
PRKACB
RACK1
RANBP9
RCHY1
RPL11
RPL5
SIRT1
SMAD2
SMAD3
SP1
SP3
SUMO1
TP53
TP63
TRIM28
UBE2D3
UBE2I
WT1
WWOX
XPO1
YAP1
Entrez ID
701
7161
HPRD ID
04176
03587
Ensembl ID
ENSG00000156970
ENSG00000078900
Uniprot IDs
O60566
A0A0C4DFW9
A1PQX5
O15350
PDB IDs
2WVI
3SI5
4GGD
5JJA
5K6S
5KHU
5LCW
5SWF
6TLJ
1COK
1DXS
2KBY
2MPS
2NB1
2WQI
2WQJ
2WTT
2XWC
3VD0
3VD1
3VD2
4A63
4G82
4G83
4GUO
4GUQ
5HOB
5HOC
5KBD
6FGS
6IJQ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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