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TP73 and XPO1
Data Source:
BioGRID
(unspecified method)
TP73
XPO1
Description
tumor protein p73
exportin 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cell Junction
Intracellular Membrane-bounded Organelle
Kinetochore
Nucleus
Nuclear Envelope
Annulate Lamellae
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cajal Body
Membrane
Nuclear Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Host Cell
Ribonucleoprotein Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Identical Protein Binding
Metal Ion Binding
MDM2/MDM4 Family Protein Binding
RNA Binding
Nuclear Export Signal Receptor Activity
Protein Binding
Biological Process
Activation Of MAPK Activity
Kidney Development
Mismatch Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Regulation Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Organonitrogen Compound
Regulation Of Gene Expression
Viral Process
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Protein Tetramerization
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Hematopoietic Stem Cell Differentiation
Ribosomal Subunit Export From Nucleus
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
Protein Export From Nucleus
Nucleocytoplasmic Transport
Viral Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ribosome Biogenesis
Regulation Of MRNA Stability
MRNA Transport
Intracellular Transport Of Virus
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Rev-mediated nuclear export of HIV RNA
NEP/NS2 Interacts with the Cellular Export Machinery
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Deactivation of the beta-catenin transactivating complex
HuR (ELAVL1) binds and stabilizes mRNA
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Mitotic Prometaphase
Cyclin A/B1/B2 associated events during G2/M transition
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
EML4 and NUDC in mitotic spindle formation
Drugs
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Selinexor
Diseases
Hepatocellular carcinoma
GWAS
Joint damage in rheumatoid arthritis (
31596875
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Visceral fat (
22589738
)
Waist-hip ratio (
28552196
)
Atrial fibrillation (
29892015
)
Eosinophil counts (
32888494
27863252
)
Erectile dysfunction (
30583798
)
Mean reticulocyte volume (
32888494
)
Neutrophil count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
Urinary sodium excretion (
31409800
)
White blood cell count (
32888494
)
Interacting Genes
63 interacting genes:
ABL1
ATF3
AURKA
BIN1
BUB1B
CABLES1
CCNB1
CCND1
CCNE1
CDK1
CDK2
CEBPZ
CHD3
CREBBP
CSNK2A1
DAXX
DDB1
EP300
FBXO45
FLNA
HCK
HECW2
HIPK2
HIPK3
HMGB1
HRAS
IKBKB
ITCH
KAT2B
MAPK8
MDM2
MDM4
MUL1
MYC
NEDD4
NFYB
PFDN5
PIAS1
PIN1
PLK1
PML
PPP1R13B
PRKACB
RACK1
RANBP9
RCHY1
RPL11
RPL5
SIRT1
SMAD2
SMAD3
SP1
SP3
SUMO1
TP53
TP63
TRIM28
UBE2D3
UBE2I
WT1
WWOX
XPO1
YAP1
80 interacting genes:
ABL1
ADAR
AGFG1
AHR
ANP32A
ANP32B
APC
ATF2
BECN1
BIRC5
BRCA2
CCND1
CDC25A
CDC42
CDCA4
CDKN1B
CHEK1
CHORDC1
CIITA
CRK
DDX3X
DESI1
DR1
E2F4
E2F5
EIF5A
ERF
FBXO7
FOXO4
HDAC3
HNF4A
HSPA9
HSPB1
IRF5
KIF17
LINC01554
MAPK6
NF2
NMD3
NPM1
NUCB1
NUCB2
NUP153
NUP214
NUP50
NUP62
NXF3
NXT1
ORC1
PHAX
PHB
PKIA
RAD51
RAN
RANBP2
RANBP3
RCC1
RCN2
RGS14
RIC8A
RPS6KB1
SERPINB1
SERTAD2
SIRT2
SMAD1
SMARCB1
SMURF1
SMURF2
SNUPN
SOX2
STAT1
STRADA
SUMO1
SUMO2
TERF2IP
TERT
TOP2A
TOP2B
TP53
TP73
Entrez ID
7161
7514
HPRD ID
03587
03975
Ensembl ID
ENSG00000078900
ENSG00000082898
Uniprot IDs
A0A0C4DFW9
A1PQX5
O15350
B3KWD0
O14980
PDB IDs
1COK
1DXS
2KBY
2MPS
2NB1
2WQI
2WQJ
2WTT
2XWC
3VD0
3VD1
3VD2
4A63
4G82
4G83
4GUO
4GUQ
5HOB
5HOC
5KBD
6FGS
6IJQ
1W9C
2L1L
3GB8
4BSM
4BSN
5DIS
6TVO
Enriched GO Terms of Interacting Partners
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