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BUB1B
Description
BUB1 mitotic checkpoint serine/threonine kinase B
Image
GO Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome Kinetochore
Condensed Chromosome Outer Kinetochore
Anaphase-promoting Complex
Cytoplasm
Microtubule Organizing Center
Spindle
Cytosol
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Mitotic Cell Cycle
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Checkpoint
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Catabolic Process
Cell Division
Meiotic Sister Chromatid Cohesion, Centromeric
Protein Localization To Chromosome, Centromeric Region
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
28165464
24292274
)
Interacting Genes
26 interacting genes:
ANAPC7
AP1B1
AP2B1
AP3B1
AP4B1
APC
BRCA2
BUB3
CCNA2
CDC16
CDC20
CDC27
CENPE
COMMD4
DNMBP
FBXO7
FZR1
HDAC1
KNL1
MAP3K4
PELI1
PLK1
RIPK3
SNCG
TP73
TRIP13
Entrez ID
701
HPRD ID
04176
Ensembl ID
ENSG00000156970
Uniprot IDs
O60566
PDB IDs
2WVI
3SI5
4GGD
5JJA
5K6S
5KHU
5LCW
5SWF
6TLJ
Enriched GO Terms of Interacting Partners
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