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TP73 and HCK
Data Source:
BioGRID
(affinity chromatography technology, pull down, enzymatic study)
TP73
HCK
Description
tumor protein p73
HCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cell Junction
Intracellular Membrane-bounded Organelle
Nucleus
Lysosome
Golgi Apparatus
Cytosol
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Transport Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Projection
Intracellular Membrane-bounded Organelle
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Identical Protein Binding
Metal Ion Binding
MDM2/MDM4 Family Protein Binding
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Biological Process
Activation Of MAPK Activity
Kidney Development
Mismatch Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Regulation Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Organonitrogen Compound
Regulation Of Gene Expression
Viral Process
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Protein Tetramerization
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Hematopoietic Stem Cell Differentiation
Leukocyte Migration Involved In Immune Response
Innate Immune Response-activating Signal Transduction
Protein Phosphorylation
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Positive Regulation Of Actin Filament Polymerization
Lipopolysaccharide-mediated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Apoptotic Process
Leukocyte Degranulation
Innate Immune Response
Respiratory Burst After Phagocytosis
Protein Autophosphorylation
Regulation Of Defense Response To Virus By Virus
Regulation Of Inflammatory Response
Regulation Of Phagocytosis
Regulation Of DNA-binding Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Podosome Assembly
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Nef and signal transduction
FCGR activation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Drugs
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Phosphonotyrosine
Quercetin
Bosutinib
Fostamatinib
Diseases
Hepatocellular carcinoma
GWAS
Joint damage in rheumatoid arthritis (
31596875
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Visceral fat (
22589738
)
Waist-hip ratio (
28552196
)
Adult body size (
32376654
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Inflammatory bowel disease (
23128233
)
Migraine (
27322543
)
Interacting Genes
63 interacting genes:
ABL1
ATF3
AURKA
BIN1
BUB1B
CABLES1
CCNB1
CCND1
CCNE1
CDK1
CDK2
CEBPZ
CHD3
CREBBP
CSNK2A1
DAXX
DDB1
EP300
FBXO45
FLNA
HCK
HECW2
HIPK2
HIPK3
HMGB1
HRAS
IKBKB
ITCH
KAT2B
MAPK8
MDM2
MDM4
MUL1
MYC
NEDD4
NFYB
PFDN5
PIAS1
PIN1
PLK1
PML
PPP1R13B
PRKACB
RACK1
RANBP9
RCHY1
RPL11
RPL5
SIRT1
SMAD2
SMAD3
SP1
SP3
SUMO1
TP53
TP63
TRIM28
UBE2D3
UBE2I
WT1
WWOX
XPO1
YAP1
116 interacting genes:
ABL1
ABL2
ACTB
ADAM15
AGK
AGR2
APP
AR
ARRB1
ASAP1
BCAR1
BCR
BPIFA1
BTK
CBL
CCDC88B
CCR3
CD2AP
CHST15
CREBBP
CSF2RB
CSF3R
CSK
CTAG1A
CTAG1B
CYB5D2
CYSRT1
DNM2
DOK1
DOK2
EGFR
ELMO1
ERBB2
ERBB3
ERBB4
EVL
FASLG
FCGR1A
FCGR2A
FHL2
FHL5
GAB1
GOPC
GRB14
HNRNPK
HSF2BP
IL6ST
INCA1
INPP5D
IRF2BPL
KHDRBS1
KIT
KPRP
KRT31
KRT34
KRT35
KRT36
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-1
LCP2
LETMD1
LMNA
MAP4K5
MDK
MDM2
MET
MID2
MKRN3
MTUS2
NBPF19
NGEF
NOTCH2NLA
PAK2
PECAM1
PIK3CB
PIK3R1
PIK3R2
PLAUR
PLCG1
PLCG2
PLEKHG4
PNMA1
RAPGEF1
RASA1
RASA3
RBPMS
RPL10
SF3B3
SH2B2
SH3BP1
SH3KBP1
SKAP2
SOS1
SPRR2A
STAT3
TEKT4
TEPSIN
TNK2
TOX2
TP73
TRIM27
TRIP6
TRPV4
TSG101
UNC119
VAV1
WAS
WDCP
WIPF1
WNT2
ZSCAN4
Entrez ID
7161
3055
HPRD ID
03587
00796
Ensembl ID
ENSG00000078900
ENSG00000101336
Uniprot IDs
A0A0C4DFW9
A1PQX5
O15350
A8K4G3
P08631
PDB IDs
1COK
1DXS
2KBY
2MPS
2NB1
2WQI
2WQJ
2WTT
2XWC
3VD0
3VD1
3VD2
4A63
4G82
4G83
4GUO
4GUQ
5HOB
5HOC
5KBD
6FGS
6IJQ
1AD5
1BU1
1QCF
2C0I
2C0O
2C0T
2HCK
2HK5
2OI3
2OJ2
3HCK
3NHN
3RBB
3REA
3REB
3VRY
3VRZ
3VS0
3VS1
3VS2
3VS3
3VS4
3VS5
3VS6
3VS7
4HCK
4LUD
4LUE
4ORZ
4U5W
5H09
5H0B
5H0E
5H0G
5H0H
5HCK
5NUH
5ZJ6
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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