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TP73 and RANBP9
Data Source:
BioGRID
(pull down, affinity chromatography technology)
TP73
RANBP9
Description
tumor protein p73
RAN binding protein 9
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cell Junction
Intracellular Membrane-bounded Organelle
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Associated Complex
Plasma Membrane
Nuclear Body
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Identical Protein Binding
Metal Ion Binding
MDM2/MDM4 Family Protein Binding
Protein Binding
Enzyme Binding
Biological Process
Activation Of MAPK Activity
Kidney Development
Mismatch Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Regulation Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Organonitrogen Compound
Regulation Of Gene Expression
Viral Process
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Protein Tetramerization
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Hematopoietic Stem Cell Differentiation
MAPK Cascade
Cytoskeleton Organization
Microtubule Nucleation
Cell Surface Receptor Signaling Pathway
Axon Guidance
Protein-containing Complex Assembly
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs
L1CAM interactions
RAF/MAP kinase cascade
MET activates RAS signaling
Drugs
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Hepatocellular carcinoma
GWAS
Joint damage in rheumatoid arthritis (
31596875
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Visceral fat (
22589738
)
Waist-hip ratio (
28552196
)
Breast cancer (
29059683
23535729
)
Interacting Genes
63 interacting genes:
ABL1
ATF3
AURKA
BIN1
BUB1B
CABLES1
CCNB1
CCND1
CCNE1
CDK1
CDK2
CEBPZ
CHD3
CREBBP
CSNK2A1
DAXX
DDB1
EP300
FBXO45
FLNA
HCK
HECW2
HIPK2
HIPK3
HMGB1
HRAS
IKBKB
ITCH
KAT2B
MAPK8
MDM2
MDM4
MUL1
MYC
NEDD4
NFYB
PFDN5
PIAS1
PIN1
PLK1
PML
PPP1R13B
PRKACB
RACK1
RANBP9
RCHY1
RPL11
RPL5
SIRT1
SMAD2
SMAD3
SP1
SP3
SUMO1
TP53
TP63
TRIM28
UBE2D3
UBE2I
WT1
WWOX
XPO1
YAP1
56 interacting genes:
ADAP1
ADAP2
APC
AR
ATM
AXL
BACE1
BRCA1
CACNA1G
CALB1
CBS
CCND1
CDK11B
CLEC7A
DDX4
DISC1
DYRK1B
ENTPD1
ESR1
EXOC2
FMR1
HIPK2
HMBS
HNF4G
ITGAL
ITGB2
L1CAM
LMNA
MAPK6
MET
MPHOSPH8
NCOA6
NCOR2
NSRP1
PPARD
PPARG
PPP1CA
PRKACA
RAF1
RAN
S100A7
SMAD2
SMAD3
SMAD9
SOS1
SPOP
SPP1
TFRC
THRA
THRB
TP53
TP73
UCHL1
USP11
WNK1
YPEL5
Entrez ID
7161
10048
HPRD ID
03587
04835
Ensembl ID
ENSG00000078900
ENSG00000010017
Uniprot IDs
A0A0C4DFW9
A1PQX5
O15350
A0A024QZW3
Q96S59
PDB IDs
1COK
1DXS
2KBY
2MPS
2NB1
2WQI
2WQJ
2WTT
2XWC
3VD0
3VD1
3VD2
4A63
4G82
4G83
4GUO
4GUQ
5HOB
5HOC
5KBD
6FGS
6IJQ
5JI7
5JI9
5JIU
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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