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TP73 and RCHY1
Data Source:
BioGRID
(enzymatic study)
TP73
RCHY1
Description
tumor protein p73
ring finger and CHY zinc finger domain containing 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cell Junction
Intracellular Membrane-bounded Organelle
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Speck
Intracellular Membrane-bounded Organelle
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Identical Protein Binding
Metal Ion Binding
MDM2/MDM4 Family Protein Binding
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Biological Process
Activation Of MAPK Activity
Kidney Development
Mismatch Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Regulation Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Organonitrogen Compound
Regulation Of Gene Expression
Viral Process
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Protein Tetramerization
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Hematopoietic Stem Cell Differentiation
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Error-free Translesion Synthesis
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Translesion Synthesis by POLH
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Hepatocellular carcinoma
GWAS
Joint damage in rheumatoid arthritis (
31596875
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Visceral fat (
22589738
)
Waist-hip ratio (
28552196
)
Metabolite levels (
23823483
)
Response to tocilizumab in rheumatoid arthritis (
22491018
)
Interacting Genes
63 interacting genes:
ABL1
ATF3
AURKA
BIN1
BUB1B
CABLES1
CCNB1
CCND1
CCNE1
CDK1
CDK2
CEBPZ
CHD3
CREBBP
CSNK2A1
DAXX
DDB1
EP300
FBXO45
FLNA
HCK
HECW2
HIPK2
HIPK3
HMGB1
HRAS
IKBKB
ITCH
KAT2B
MAPK8
MDM2
MDM4
MUL1
MYC
NEDD4
NFYB
PFDN5
PIAS1
PIN1
PLK1
PML
PPP1R13B
PRKACB
RACK1
RANBP9
RCHY1
RPL11
RPL5
SIRT1
SMAD2
SMAD3
SP1
SP3
SUMO1
TP53
TP63
TRIM28
UBE2D3
UBE2I
WT1
WWOX
XPO1
YAP1
75 interacting genes:
ADAMTSL4
AIG1
ANGPTL8
AOX1
AR
ARF4
ATN1
BIRC3
CAMK2A
CAMK2G
CDK9
CDKN1B
CHD8
CHEK2
COPE
COX6C
CREB5
CYBA
DAPK1
DCUN1D5
F7
FADS6
GFI1B
GORAB
HOXA1
HOXA2
HOXA3
HOXB1
HOXB2
HOXB5
HOXC11
HOXC4
HOXD10
HRG
KAT5
KLHL41
KRTAP9-2
LIMS2
MDM2
MEOX2
MSH3
MT2A
NKD2
NLK
NOTCH2NLA
PGLS
PLAGL2
PMM1
PRDX4
RAB11A
RBM38
RILP
RPLP1
RPN2
SEMA4C
SERPINA1
SERPINA5
SERTAD1
SRPRB
TAOK2
TMBIM1
TMEM14C
TMEM184A
TP53
TP63
TP73
TRIM8
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
WDR74
ZNF160
Entrez ID
7161
25898
HPRD ID
03587
07607
Ensembl ID
ENSG00000078900
ENSG00000163743
Uniprot IDs
A0A0C4DFW9
A1PQX5
O15350
Q96PM5
PDB IDs
1COK
1DXS
2KBY
2MPS
2NB1
2WQI
2WQJ
2WTT
2XWC
3VD0
3VD1
3VD2
4A63
4G82
4G83
4GUO
4GUQ
5HOB
5HOC
5KBD
6FGS
6IJQ
2JRJ
2K2C
2K2D
Enriched GO Terms of Interacting Partners
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