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BRCA2 and FLNA
Data Source:
BioGRID
(pull down, affinity chromatography technology, two hybrid)
HPRD
(in vitro, two hybrid, in vivo)
BRCA2
FLNA
Description
BRCA2 DNA repair associated
filamin A
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Centrosome
Cytosol
Secretory Granule
Protein-containing Complex
BRCA2-MAGE-D1 Complex
Extracellular Region
Nucleus
Nucleolus
Cytoplasm
Trans-Golgi Network
Cytosol
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Z Disc
Cortical Cytoskeleton
Myb Complex
Actin Filament Bundle
Dendritic Shaft
Perikaryon
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Apical Dendrite
Postsynapse
Glutamatergic Synapse
Molecular Function
Protease Binding
Single-stranded DNA Binding
Histone Acetyltransferase Activity
Protein Binding
Protein C-terminus Binding
H3 Histone Acetyltransferase Activity
H4 Histone Acetyltransferase Activity
Identical Protein Binding
Gamma-tubulin Binding
G Protein-coupled Receptor Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Kinase Binding
Small GTPase Binding
Mu-type Opioid Receptor Binding
Fc-gamma Receptor I Complex Binding
Protein Homodimerization Activity
Ion Channel Binding
Cadherin Binding
SMAD Binding
Actin Filament Binding
GTPase Binding
Biological Process
Telomere Maintenance Via Recombination
Double-strand Break Repair Via Homologous Recombination
Oocyte Maturation
Inner Cell Mass Cell Proliferation
Nucleotide-excision Repair
Double-strand Break Repair
Regulation Of Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Male Meiosis I
Spermatogenesis
Brain Development
Cell Aging
Female Gonad Development
Response To X-ray
Response To UV-C
Response To Gamma Radiation
Hemopoiesis
Regulation Of Cytokinesis
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Histone H3 Acetylation
Histone H4 Acetylation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Mitotic Cell Cycle
Replication Fork Protection
Centrosome Duplication
Establishment Of Protein Localization To Telomere
Mitotic Recombination-dependent Replication Fork Processing
Angiogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Platelet Degranulation
Heart Morphogenesis
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Transcription By RNA Polymerase I
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Platelet Activation
Regulation Of Cell Migration
Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Filament Bundle Assembly
Cell Junction Assembly
Protein Localization To Cell Surface
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Import Into Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of DNA-binding Transcription Factor Activity
Wound Healing, Spreading Of Cells
Early Endosome To Late Endosome Transport
Establishment Of Protein Localization
Cell-cell Junction Organization
Positive Regulation Of Axon Regeneration
Synapse Organization
Protein Stabilization
Cytoplasmic Sequestering Of Protein
Defense Response To Virus
Actin Crosslink Formation
Cilium Assembly
Platelet Aggregation
Semaphorin-plexin Signaling Pathway
Protein Localization To Plasma Membrane
Tubulin Deacetylation
Mitotic Spindle Assembly
Establishment Of Sertoli Cell Barrier
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Potassium Ion Transmembrane Transport
Protein Localization To Bicellular Tight Junction
Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential
Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Integrin-mediated Signaling Pathway
Positive Regulation Of Neuron Migration
Pathways
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Meiotic recombination
Platelet degranulation
GP1b-IX-V activation signalling
Cell-extracellular matrix interactions
RHO GTPases activate PAKs
OAS antiviral response
Drugs
Artenimol
Diseases
Fanconi anemia
Pancreatic cancer
Breast cancer
Ovarian cancer
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
Periventricular nodular heterotopia (PVNH)
FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS
Apolipoprotein B levels (
32203549
)
Basal cell carcinoma (
31174203
)
Breast cancer (
29059683
23535729
23535733
)
Cancer (
27197191
)
Cancer (pleiotropy) (
27197191
)
Cutaneous squamous cell carcinoma (
32041948
)
Keratinocyte cancer (MTAG) (
31174203
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
32203549
28334899
)
Lung cancer (
28604730
24880342
)
Lung cancer in ever smokers (
28604730
)
Small cell lung carcinoma (
28604730
)
Squamous cell carcinoma (
31174203
)
Squamous cell lung carcinoma (
28604730
)
Immature fraction of reticulocytes (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
49 interacting genes:
ATM
ATR
BCCIP
BRCA1
BUB1B
CCNA1
CCNA2
CCND1
CCNE1
CDK1
CDK2
CFAP52
CHEK1
CHEK2
DMC1
DYNC1LI1
DYNC1LI2
EMSY
ERCC5
FANCD2
FANCE
FANCG
FANCI
FLNA
H2AX
HMG20B
HNRNPC
KAT2B
LIMD1
MAGED1
NEDD4
PALB2
PDS5B
PLEC
PLK1
RAD51
RNASEH2A
RPA1
SEM1
SERPINH1
SMAD3
STAT5A
TP53
TP53BP1
UQCC1
USP11
USP21
WTIP
XPO1
98 interacting genes:
ADAMTSL4
APC
AR
ARHGAP24
ARRB1
ARRB2
ASB2
BRCA1
BRCA2
CALCR
CAMK2G
CASR
CAV1
CCNB1
CDC42
CEACAM1
CMIP
DCN
DDIT4L
DRD1
DRD2
DRD3
DUX4
ERBB3
F3
FABP1
FBLIM1
FILIP1
FLNB
FURIN
GP1BA
GRIK1
GRIK3
GRM4
GRM5
GRM7
GRM8
HHLA3
HNRNPD
HSPA6
HSPB7
ITGB1
ITGB3
ITGB5
ITGB6
ITGB7
KCNE4
KCNJ2
KLHL12
LGALS14
LMNA
MAP2K4
MAPK14
MCPH1
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
NLGN3
NPHP1
OPRM1
PAK1
PCBP2
PELO
PHOSPHO2
PLEKHF2
PRKCA
PSEN1
PSEN2
RAC1
RALA
REL
RFLNA
RHOA
SELE
SH2B3
SHBG
SIGLEC10
SIRPA
SMAD3
SMAD5
SPANXD
SRC
SUMO2
SVIL
SYNPO2
TCF4
TLR10
TNIP2
TP73
TRAF2
TRIM55
TRIO
TTN
USP19
VHL
YWHAG
Entrez ID
675
2316
HPRD ID
02554
02060
Ensembl ID
ENSG00000139618
ENSG00000196924
Uniprot IDs
P51587
P21333
Q60FE5
Q6NXF2
PDB IDs
1N0W
3EU7
6GY2
6HQU
2AAV
2BP3
2BRQ
2J3S
2JF1
2K3T
2K7P
2K7Q
2MTP
2W0P
2WFN
3CNK
3HOC
3HOP
3HOR
3ISW
3RGH
4M9P
4P3W
5XR1
6D8C
6EW1
Enriched GO Terms of Interacting Partners
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