Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
BRCA2 and CCNA1
Data Source:
BioGRID
(affinity chromatography technology, pull down)
BRCA2
CCNA1
Description
BRCA2 DNA repair associated
cyclin A1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Centrosome
Cytosol
Secretory Granule
Protein-containing Complex
BRCA2-MAGE-D1 Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Molecular Function
Protease Binding
Single-stranded DNA Binding
Histone Acetyltransferase Activity
Protein Binding
Protein C-terminus Binding
H3 Histone Acetyltransferase Activity
H4 Histone Acetyltransferase Activity
Identical Protein Binding
Gamma-tubulin Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Biological Process
Telomere Maintenance Via Recombination
Double-strand Break Repair Via Homologous Recombination
Oocyte Maturation
Inner Cell Mass Cell Proliferation
Nucleotide-excision Repair
Double-strand Break Repair
Regulation Of Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Male Meiosis I
Spermatogenesis
Brain Development
Cell Aging
Female Gonad Development
Response To X-ray
Response To UV-C
Response To Gamma Radiation
Hemopoiesis
Regulation Of Cytokinesis
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Histone H3 Acetylation
Histone H4 Acetylation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Mitotic Cell Cycle
Replication Fork Protection
Centrosome Duplication
Establishment Of Protein Localization To Telomere
Mitotic Recombination-dependent Replication Fork Processing
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Protein Deubiquitination
Mitotic Cell Cycle Phase Transition
Cell Division
Pathways
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Meiotic recombination
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
Fanconi anemia
Pancreatic cancer
Breast cancer
Ovarian cancer
GWAS
Apolipoprotein B levels (
32203549
)
Basal cell carcinoma (
31174203
)
Breast cancer (
29059683
23535729
23535733
)
Cancer (
27197191
)
Cancer (pleiotropy) (
27197191
)
Cutaneous squamous cell carcinoma (
32041948
)
Keratinocyte cancer (MTAG) (
31174203
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
32203549
28334899
)
Lung cancer (
28604730
24880342
)
Lung cancer in ever smokers (
28604730
)
Small cell lung carcinoma (
28604730
)
Squamous cell carcinoma (
31174203
)
Squamous cell lung carcinoma (
28604730
)
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Interacting Genes
49 interacting genes:
ATM
ATR
BCCIP
BRCA1
BUB1B
CCNA1
CCNA2
CCND1
CCNE1
CDK1
CDK2
CFAP52
CHEK1
CHEK2
DMC1
DYNC1LI1
DYNC1LI2
EMSY
ERCC5
FANCD2
FANCE
FANCG
FANCI
FLNA
H2AX
HMG20B
HNRNPC
KAT2B
LIMD1
MAGED1
NEDD4
PALB2
PDS5B
PLEC
PLK1
RAD51
RNASEH2A
RPA1
SEM1
SERPINH1
SMAD3
STAT5A
TP53
TP53BP1
UQCC1
USP11
USP21
WTIP
XPO1
35 interacting genes:
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
XRCC6
Entrez ID
675
8900
HPRD ID
02554
04946
Ensembl ID
ENSG00000139618
ENSG00000133101
Uniprot IDs
P51587
A0A140VJG0
P78396
PDB IDs
1N0W
3EU7
6GY2
6HQU
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?