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BRCA2 and CDK1
Data Source:
HPRD
(in vitro)
BRCA2
CDK1
Description
BRCA2 DNA repair associated
cyclin dependent kinase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Centrosome
Cytosol
Secretory Granule
Protein-containing Complex
BRCA2-MAGE-D1 Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin B1-CDK1 Complex
Molecular Function
Protease Binding
Single-stranded DNA Binding
Histone Acetyltransferase Activity
Protein Binding
Protein C-terminus Binding
H3 Histone Acetyltransferase Activity
H4 Histone Acetyltransferase Activity
Identical Protein Binding
Gamma-tubulin Binding
Virus Receptor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Biological Process
Telomere Maintenance Via Recombination
Double-strand Break Repair Via Homologous Recombination
Oocyte Maturation
Inner Cell Mass Cell Proliferation
Nucleotide-excision Repair
Double-strand Break Repair
Regulation Of Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Male Meiosis I
Spermatogenesis
Brain Development
Cell Aging
Female Gonad Development
Response To X-ray
Response To UV-C
Response To Gamma Radiation
Hemopoiesis
Regulation Of Cytokinesis
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Histone H3 Acetylation
Histone H4 Acetylation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Mitotic Cell Cycle
Replication Fork Protection
Centrosome Duplication
Establishment Of Protein Localization To Telomere
Mitotic Recombination-dependent Replication Fork Processing
G2/M Transition Of Mitotic Cell Cycle
Activation Of MAPK Activity
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Nuclear Envelope Disassembly
Mitotic G2 DNA Damage Checkpoint
Centrosome Cycle
Pronuclear Fusion
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Cell Migration
Histone Phosphorylation
Protein Deubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Epithelial Cell Differentiation
Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Kinetochore
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Embryonic Development
Viral Entry Into Host Cell
Rhythmic Process
Cell Division
Golgi Disassembly
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Meiotic recombination
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
Diseases
Fanconi anemia
Pancreatic cancer
Breast cancer
Ovarian cancer
GWAS
Apolipoprotein B levels (
32203549
)
Basal cell carcinoma (
31174203
)
Breast cancer (
29059683
23535729
23535733
)
Cancer (
27197191
)
Cancer (pleiotropy) (
27197191
)
Cutaneous squamous cell carcinoma (
32041948
)
Keratinocyte cancer (MTAG) (
31174203
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
32203549
28334899
)
Lung cancer (
28604730
24880342
)
Lung cancer in ever smokers (
28604730
)
Small cell lung carcinoma (
28604730
)
Squamous cell carcinoma (
31174203
)
Squamous cell lung carcinoma (
28604730
)
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Interacting Genes
49 interacting genes:
ATM
ATR
BCCIP
BRCA1
BUB1B
CCNA1
CCNA2
CCND1
CCNE1
CDK1
CDK2
CFAP52
CHEK1
CHEK2
DMC1
DYNC1LI1
DYNC1LI2
EMSY
ERCC5
FANCD2
FANCE
FANCG
FANCI
FLNA
H2AX
HMG20B
HNRNPC
KAT2B
LIMD1
MAGED1
NEDD4
PALB2
PDS5B
PLEC
PLK1
RAD51
RNASEH2A
RPA1
SEM1
SERPINH1
SMAD3
STAT5A
TP53
TP53BP1
UQCC1
USP11
USP21
WTIP
XPO1
186 interacting genes:
ABL1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BIRC5
BIRC6
BRCA1
BRCA2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDC6
CDCA2
CDCA5
CDK7
CDKN1A
CDKN1B
CDKN3
CDT1
CEP55
CEP63
CHAF1B
CIITA
CKS2
CNOT7
CREM
CSN2
CSNK2A1
CSNK2B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EGFR
EP300
EPN1
ERCC2
FANCA
FANCC
FANCG
FBXO5
FEN1
FOXM1
FYN
GADD45A
GADD45B
GADD45G
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
IL16
IL3RA
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LYN
LZTS1
MAP4
MAPT
MARCKS
MBP
MCM4
MDM4
MEF2C
MKI67
MLKL
MNDA
MYC
MYT1
NCAPD2
NCAPG
NCAPH
NCL
NDE1
NES
NPM1
NSFL1C
NUP210
PAK6
PBK
PCNA
PIN1
PITPNM1
PKMYT1
PLEC
PML
POLA1
PPP2R1A
PPP2R1B
PPP2R2B
PRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RGCC
RPA2
RPS6KB1
RRM2
RUNX1
RUNX2
SFN
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TFDP1
TGFBR2
TK1
TLE1
TNNC1
TOP2A
TP53
TP53BP1
TP73
TSC1
TSPYL2
UBA1
UBE2A
UBE3A
UHRF2
USP16
VIM
WEE1
XIAP
ZBTB16
Entrez ID
675
983
HPRD ID
02554
00302
Ensembl ID
ENSG00000139618
ENSG00000170312
Uniprot IDs
P51587
A0A024QZJ8
B7Z3D6
I6L9I5
P06493
PDB IDs
1N0W
3EU7
6GY2
6HQU
1LC9
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
Enriched GO Terms of Interacting Partners
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