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SMN1 and VPS28
Data Source:
BioGRID
(two hybrid)
SMN1
VPS28
Description
survival of motor neuron 1, telomeric
VPS28 subunit of ESCRT-I
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cajal Body
Nuclear Body
Z Disc
Axon
SMN Complex
SMN-Sm Protein Complex
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Perikaryon
Gemini Of Coiled Bodies
ESCRT I Complex
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Late Endosome Membrane
Host Cell
Extracellular Exosome
Molecular Function
RNA Binding
Protein Binding
Identical Protein Binding
Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
Biological Process
Spliceosomal Complex Assembly
Spliceosomal SnRNP Assembly
DNA-templated Transcription, Termination
Nervous System Development
Import Into Nucleus
Endosomal Transport
Macroautophagy
Viral Life Cycle
Negative Regulation Of Protein Ubiquitination
Multivesicular Body Assembly
Viral Budding Via Host ESCRT Complex
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Positive Regulation Of Protein Catabolic Process
Intracellular Transport Of Virus
Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways
snRNP Assembly
Budding and maturation of HIV virion
Membrane binding and targetting of GAG proteins
Endosomal Sorting Complex Required For Transport (ESCRT)
HCMV Late Events
Late endosomal microautophagy
Drugs
Nusinersen
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Blood metabolite levels (
26401656
)
Educational attainment (
25201988
)
Interacting Genes
165 interacting genes:
A1BG
A2M
ACTB
ACTL6B
ADAMTS10
AGAP1
ANXA2
APLP1
ARFGAP1
ATP5F1B
ATP6V1A
BAG6
BCL2
BLOC1S6
BYSL
C9orf72
CARHSP1
CCDC90B
CENPB
CHTOP
COIL
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CSAD
DDAH2
DDX20
DHX9
DMPK
DOCK7
DUS2
DYNC1I1
EEF1A1
EEF1A2
EHHADH
EIF3G
EXT2
EZH2
FAM20C
FAM9B
FBL
FGB
FLAD1
FNDC11
FUBP1
GAPDH
GAR1
GDF9
GEMIN2
GEMIN5
GEMIN7
H3-4
HADHB
HMGXB3
HNRNPR
HNRNPU
HNRNPUL1
IGHM
ILF3
IMMT
INPP5K
IQUB
ITCH
JADE1
KDM1A
KIF5A
KLHL5
KMT2B
KPNB1
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-1
KRTAP6-2
LENG8
LRIF1
LSM1
LSM10
LSM11
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MAGED1
MAST2
MED31
MKI67
MPP1
MRPL37
MSH2
NGFR
NKIRAS2
NMT2
NRN1
NTAQ1
OSTF1
PDE4DIP
PKM
PLXNA3
POLR1C
POLR2A
POP7
PPIG
PSME1
QARS1
RBBP4
RBBP6
RBFOX2
RBM48
REX1BD
RN7SL1
RNU1-1
RNU11
RNU2-1
RNU4-1
RPL13
RPS2
RXRA
SCARNA1
SDF4
SELENOW
SEMA5B
SETDB1
SMC5
SMN2
SNORA81
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNU13
SNUPN
SP110
SPANXN2
STRAP
STXBP2
STXBP3
SULT1A3
SUMO3
SYNCRIP
TAF1C
TERC
TIAL1
TLE1
TMSB4X
TP53
TRMT2A
TUBA1A
TUBB3
UCHL1
UNC119
USP4
VPS28
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZRANB2
ZXDC
45 interacting genes:
ABI2
ASF1A
BEX2
BLZF1
CARD9
CBX5
CCDC146
CDK18
CEP57L1
COX5B
FABP3
GABARAP
GEM
GLCCI1
GOLGA2
INCA1
LMO3
MBIP
NRDE2
NXF1
PDCD6IP
PNMA5
PRKAA2
PRKAB2
RASSF5
SAXO1
SHC3
SKIL
SMN1
SMN2
SUOX
TCF12
TCF4
TRIM27
TRIM54
TSG101
TSNAX
UBA52
UBC
USHBP1
USP2
VPS37A
VPS37B
VPS37C
VPS52
Entrez ID
6606
51160
HPRD ID
02646
11675
Ensembl ID
ENSG00000172062
ENSG00000160948
Uniprot IDs
B4DP61
E7EQZ4
Q16637
A0A0S2Z5H5
Q548N1
Q9UK41
PDB IDs
1G5V
1MHN
2LEH
4A4E
4A4G
4GLI
4QQ6
5XJL
5XJQ
5XJR
5XJS
5XJT
5XJU
6VME
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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