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SMN1 and DHX9
Data Source:
BioGRID
(pull down, affinity chromatography technology)
HPRD
(in vitro)
SMN1
DHX9
Description
survival of motor neuron 1, telomeric
DExH-box helicase 9
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cajal Body
Nuclear Body
Z Disc
Axon
SMN Complex
SMN-Sm Protein Complex
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Perikaryon
Gemini Of Coiled Bodies
Intracellular Anatomical Structure
Nucleus
Nucleoplasm
Perichromatin Fibrils
Nucleolus
Cytoplasm
Centrosome
Cytosol
Polysome
Actin Cytoskeleton
Membrane
RISC Complex
Nuclear Body
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
Polysomal Ribosome
RISC-loading Complex
CRD-mediated MRNA Stability Complex
Nuclear Stress Granule
Ribonucleoprotein Complex
Molecular Function
RNA Binding
Protein Binding
Identical Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Complex Binding
Regulatory Region RNA Binding
RNA Polymerase II Transcription Factor Binding
DNA Binding
DNA Helicase Activity
DNA Replication Origin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
RNA Helicase Activity
Double-stranded RNA Binding
Single-stranded RNA Binding
MRNA Binding
Protein Binding
ATP Binding
ATPase Activity
Nucleoside-triphosphatase Activity
Chromatin DNA Binding
3'-5' DNA/RNA Helicase Activity
3'-5' RNA Helicase Activity
SiRNA Binding
RNA Stem-loop Binding
3'-5' DNA Helicase Activity
Triplex DNA Binding
Metal Ion Binding
Nucleoside-triphosphate Diphosphatase Activity
Importin-alpha Family Protein Binding
RNA Polymerase Binding
RISC Complex Binding
Polysome Binding
Single-stranded 3'-5' DNA Helicase Activity
Sequence-specific MRNA Binding
Promoter-specific Chromatin Binding
Biological Process
Spliceosomal Complex Assembly
Spliceosomal SnRNP Assembly
DNA-templated Transcription, Termination
Nervous System Development
Import Into Nucleus
Alternative MRNA Splicing, Via Spliceosome
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
DNA Replication
DNA-templated Transcription, Termination
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
RNA Secondary Structure Unwinding
Targeting Of MRNA For Destruction Involved In RNA Interference
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Protein-containing Complex Assembly
DNA-templated Viral Transcription
G-quadruplex DNA Unwinding
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Export From Nucleus
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Positive Regulation Of Viral Transcription
Regulation Of MRNA Processing
Regulation Of Defense Response To Virus By Host
Positive Regulation Of Inflammatory Response
MRNA Transport
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Response To Cytokine Stimulus
Pyroptosis
Small RNA Loading Onto RISC
CRD-mediated MRNA Stabilization
Cellular Response To Tumor Necrosis Factor
Cellular Response To Exogenous DsRNA
Protein Localization To Cytoplasmic Stress Granule
Positive Regulation Of Viral Translation
Positive Regulation Of Polysome Binding
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Positive Regulation Of Gene Silencing By MiRNA
Regulation Of Cytoplasmic Translation
Positive Regulation Of Cytoplasmic Translation
Pathways
snRNP Assembly
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
mRNA Splicing - Major Pathway
Drugs
Nusinersen
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes
165 interacting genes:
A1BG
A2M
ACTB
ACTL6B
ADAMTS10
AGAP1
ANXA2
APLP1
ARFGAP1
ATP5F1B
ATP6V1A
BAG6
BCL2
BLOC1S6
BYSL
C9orf72
CARHSP1
CCDC90B
CENPB
CHTOP
COIL
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CSAD
DDAH2
DDX20
DHX9
DMPK
DOCK7
DUS2
DYNC1I1
EEF1A1
EEF1A2
EHHADH
EIF3G
EXT2
EZH2
FAM20C
FAM9B
FBL
FGB
FLAD1
FNDC11
FUBP1
GAPDH
GAR1
GDF9
GEMIN2
GEMIN5
GEMIN7
H3-4
HADHB
HMGXB3
HNRNPR
HNRNPU
HNRNPUL1
IGHM
ILF3
IMMT
INPP5K
IQUB
ITCH
JADE1
KDM1A
KIF5A
KLHL5
KMT2B
KPNB1
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-1
KRTAP6-2
LENG8
LRIF1
LSM1
LSM10
LSM11
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MAGED1
MAST2
MED31
MKI67
MPP1
MRPL37
MSH2
NGFR
NKIRAS2
NMT2
NRN1
NTAQ1
OSTF1
PDE4DIP
PKM
PLXNA3
POLR1C
POLR2A
POP7
PPIG
PSME1
QARS1
RBBP4
RBBP6
RBFOX2
RBM48
REX1BD
RN7SL1
RNU1-1
RNU11
RNU2-1
RNU4-1
RPL13
RPS2
RXRA
SCARNA1
SDF4
SELENOW
SEMA5B
SETDB1
SMC5
SMN2
SNORA81
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNU13
SNUPN
SP110
SPANXN2
STRAP
STXBP2
STXBP3
SULT1A3
SUMO3
SYNCRIP
TAF1C
TERC
TIAL1
TLE1
TMSB4X
TP53
TRMT2A
TUBA1A
TUBB3
UCHL1
UNC119
USP4
VPS28
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZRANB2
ZXDC
43 interacting genes:
ACTA1
AKAP8L
APBB1
BRCA1
DDX20
DDX5
DUX4
EIF2AK2
ESR1
GEMIN2
GEMIN4
GTF2B
H2AX
HDLBP
HNRNPC
HNRNPK
IL7R
ILF3
JUN
KHDRBS1
LINC01554
MBD2
NXF1
OGA
PCNA
POLR2A
PRMT1
PRPF40A
PRPF8
PTEN
RBM4
RELA
SMN1
SMN2
SNRPB
SNRPB2
SRPK1
SSRP1
STAU1
TBP
TOP2A
UBE2I
YWHAQ
Entrez ID
6606
1660
HPRD ID
02646
04386
Ensembl ID
ENSG00000172062
ENSG00000135829
Uniprot IDs
B4DP61
E7EQZ4
Q16637
B3KU66
Q08211
PDB IDs
1G5V
1MHN
2LEH
4A4E
4A4G
4GLI
4QQ6
5XJL
5XJQ
5XJR
5XJS
5XJT
5XJU
3LLM
3VYX
3VYY
Enriched GO Terms of Interacting Partners
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