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VPS28 and CARD9
Data Source:
BioGRID
(two hybrid, two hybrid)
VPS28
CARD9
Description
VPS28 subunit of ESCRT-I
caspase recruitment domain family member 9
Image
GO Annotations
Cellular Component
ESCRT I Complex
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Late Endosome Membrane
Host Cell
Extracellular Exosome
Cytoplasm
Cytosol
Plasma Membrane
Protein-containing Complex
Molecular Function
Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
Protein Binding
Protein Homodimerization Activity
CARD Domain Binding
Biological Process
Endosomal Transport
Macroautophagy
Viral Life Cycle
Negative Regulation Of Protein Ubiquitination
Multivesicular Body Assembly
Viral Budding Via Host ESCRT Complex
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Positive Regulation Of Protein Catabolic Process
Intracellular Transport Of Virus
Positive Regulation Of Ubiquitin-dependent Endocytosis
Stimulatory C-type Lectin Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Response To Fungus
Response To Peptidoglycan
Response To Muramyl Dipeptide
Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Response To Drug
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Defense Response To Virus
Pathways
Budding and maturation of HIV virion
Membrane binding and targetting of GAG proteins
Endosomal Sorting Complex Required For Transport (ESCRT)
HCMV Late Events
Late endosomal microautophagy
NOD1/2 Signaling Pathway
CLEC7A (Dectin-1) signaling
Drugs
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS
Blood metabolite levels (
26401656
)
Educational attainment (
25201988
)
Acute insulin response (insulin secretion adjusted) (
28490609
)
Ankylosing spondylitis (
23749187
21743469
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
22936669
21102463
)
IgA nephropathy (
25305756
)
Inflammatory bowel disease (
28067908
23128233
)
Joint damage in rheumatoid arthritis (
26498133
)
Large artery stroke (
28265093
)
Monocyte chemoattractant protein-1 levels (
23017229
)
Obesity-related traits (
23251661
)
Pediatric autoimmune diseases (
26301688
)
Ulcerative colitis (
19915572
28067908
20228799
21297633
)
Interacting Genes
45 interacting genes:
ABI2
ASF1A
BEX2
BLZF1
CARD9
CBX5
CCDC146
CDK18
CEP57L1
COX5B
FABP3
GABARAP
GEM
GLCCI1
GOLGA2
INCA1
LMO3
MBIP
NRDE2
NXF1
PDCD6IP
PNMA5
PRKAA2
PRKAB2
RASSF5
SAXO1
SHC3
SKIL
SMN1
SMN2
SUOX
TCF12
TCF4
TRIM27
TRIM54
TSG101
TSNAX
UBA52
UBC
USHBP1
USP2
VPS37A
VPS37B
VPS37C
VPS52
138 interacting genes:
ABLIM1
AMOTL2
AXIN1
BCL10
BLZF1
C1orf94
C2CD6
CABP2
CARD10
CBX8
CCDC13
CCDC136
CCDC85B
CCDC88B
CCHCR1
CDC37
CDCA7L
CDK2AP1
CEP57L1
CEP70
CSNK2A1
CWF19L2
DAXX
DISC1
DUSP13
DVL2
EFHC2
EIF4A3
EIF4E2
FAM124B
FAM161A
FAM161B
FAM50B
FAM90A1
FOXD4L1
GAS8
GEM
HMBOX1
HOXB5
HSF2BP
IHO1
IKZF3
INO80B
IQCE
KANK2
KCTD9
KIAA0408
KIAA1328
KIF9
KIFC3
KRT15
KRT16
KRT19
KRT31
KRT40
KRT75
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP5-7
L3MBTL2
LENG1
LMO1
LMO3
LNX1
LZTS1
LZTS2
MCRS1
MEOX2
MFAP1
MID2
MYO15B
NECAB2
NTAQ1
PAK5
PBX2
PHC2
PIBF1
PICK1
PKP2
PNMA5
PPP1R18
PRPF18
PSMA4
RBAK
RTP5
SAXO1
SCNM1
SHISA6
SLAIN1
SSX2IP
STMN3
STX11
SUMO1
TASOR2
TCEANC
TCL1A
TEX33
TFIP11
TLE5
TNFAIP1
TNS4
TRIM14
TRIM23
TRIM29
TRIM42
TRIM54
TRIM62
TSGA10IP
TSNAX
UBE2I
UNKL
USH1G
USP15
USP2
VCPKMT
VPS28
YES1
ZBTB16
ZC2HC1C
ZCCHC7
ZGPAT
ZMYM5
ZNF121
ZNF19
ZNF20
ZNF250
ZNF417
ZNF426
ZNF572
ZNF587
ZNF620
ZNF655
ZNF688
ZNF774
ZNF829
ZRANB1
ZZZ3
Entrez ID
51160
64170
HPRD ID
11675
06236
Ensembl ID
ENSG00000160948
ENSG00000187796
Uniprot IDs
A0A0S2Z5H5
Q548N1
Q9UK41
A0A024R8F1
Q9H257
PDB IDs
6VME
6E25
6E26
6E27
6E28
6N2M
6N2P
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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