BMX and FBXO25

Data Source:
BioGRID (enzymatic study)

		BMX	FBXO25
Description		BMX non-receptor tyrosine kinase	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Ruffle Membrane	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Adaptive Immune Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation B Cell Receptor Signaling Pathway	Protein Ubiquitination
Pathways		Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS			Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		26 interacting genes: APP BCAR1 BIRC2 BTK CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR NOPCHAP1 PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		660	26260
HPRD ID		02111	16439
Ensembl ID		ENSG00000102010	ENSG00000147364
Uniprot IDs		P51813	A0A024QZ88 Q8TCJ0
PDB IDs		2EKX 2YS2 3SXR 3SXS 6I99
Enriched GO Terms of Interacting Partners?
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