RTN4R and OTX1

Data Source:
BioGRID (two hybrid)

		RTN4R	OTX1
Description		reticulon 4 receptor	orthodenticle homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of External Side Of Plasma Membrane Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Protein Binding Heparin Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Ganglioside GM1 Binding Ganglioside GT1b Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration Negative Regulation Of Axonogenesis	Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Metencephalon Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis
Pathways		Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Obesity-related traits ( 23251661)	Fruit consumption ( 32066663) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		9 interacting genes: HOXA1 LINGO1 MAG MGAT5B NGFR OMG OTX1 RTN4 RTN4IP1	144 interacting genes: ADAM12 ADAMTSL4 ALPP ANKRD10 ARHGEF17 ARID5A ATG9B BHLHB9 C10orf55 C11orf1 CCN4 CERCAM CH25H CHIC2 CHRD CHRDL2 COL8A1 COMP CTAG2 CYSRT1 DPY30 EFEMP2 ETFDH FAM168B FAM72B FBLN2 FBLN5 FHL5 GEMIN8P4 GPRIN2 GRN HIVEP1 INTS11 KCNK16 KLHL26 KPRP KRT31 KRT35 KRT37 KRT81 KRT85 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LGALS13 M1AP MDFI MGAT5B MIIP MTNR1B NBPF19 NDUFAF6 NECTIN3 NHLRC4 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLEKHG4 PLSCR2 POU2AF1 PRICKLE4 PRR13 PRR22 RBPMS RGS17 RGS19 RGS20 RNF144B RTN4R SLC15A2 SMARCC1 SPRY1 SPRY2 SPRY4 SPRYD7 TEX37 TLE4 TNS2 TRIM42 TRIP6 TSPAN4 UBAP2 USP54 VWC2 VWC2L WWOX YPEL3 ZBTB42 ZNF330 ZNF34
Entrez ID		65078	5013
HPRD ID		16123	08964
Ensembl ID		ENSG00000040608	ENSG00000115507
Uniprot IDs		Q9BZR6	P32242
PDB IDs		1OZN 1P8T
Enriched GO Terms of Interacting Partners?
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