RTN4R and RTN4IP1

Data Source:
HPRD (in vitro)

		RTN4R	RTN4IP1
Description		reticulon 4 receptor	reticulon 4 interacting protein 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of External Side Of Plasma Membrane Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome	Mitochondrion Mitochondrial Outer Membrane
	Molecular Function	Protein Binding Heparin Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Ganglioside GM1 Binding Ganglioside GT1b Binding	Protein Binding Zinc Ion Binding Oxidoreductase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration Negative Regulation Of Axonogenesis	Nervous System Development Regulation Of Dendrite Development
Pathways		Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Obesity-related traits ( 23251661)	Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: HOXA1 LINGO1 MAG MGAT5B NGFR OMG OTX1 RTN4 RTN4IP1	23 interacting genes: ARFGAP3 CALCOCO2 CBFA2T3 CENPK CTAG1A CTAG1B ERMN EXOC7 GGA2 HDX MARCHF5 PPP1R8 PYM1 RELA RTN4 RTN4R RUNX1T1 SCAF1 SMURF2 SORBS1 WBP11 WWTR1 ZYX
Entrez ID		65078	84816
HPRD ID		16123	18008
Ensembl ID		ENSG00000040608	ENSG00000130347
Uniprot IDs		Q9BZR6	Q8WWV3
PDB IDs		1OZN 1P8T	2VN8
Enriched GO Terms of Interacting Partners?
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