SFTPC and TMPRSS2

Data Source:
BioGRID (two hybrid)

		SFTPC	TMPRSS2
Description		surfactant protein C	transmembrane serine protease 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Respiratory Gaseous Exchange By Respiratory System Cellular Protein Metabolic Process	Proteolysis Endocytosis Protein Autoprocessing Positive Regulation Of Viral Entry Into Host Cell
Pathways		Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Attachment and Entry Attachment and Entry Attachment and Entry
Drugs			Camostat
Diseases		Pulmonary surfactant metabolism dysfunction (SMDP)	Prostate cancer
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Prostate cancer ( 25217961)
Interacting Genes		36 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 PVR SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2	59 interacting genes: ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF UPK2 VAMP5 ZFPL1
Entrez ID		6440	7113
HPRD ID		01520	03637
Ensembl ID		ENSG00000168484	ENSG00000184012
Uniprot IDs		A0A0A0MTC9 A0A0S2Z4Q0 E5RI64 P11686	O15393
PDB IDs		2YAD
Enriched GO Terms of Interacting Partners?
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