SFTPC and CXCL9

Data Source:
BioGRID (two hybrid, two hybrid)

		SFTPC	CXCL9
Description		surfactant protein C	C-X-C motif chemokine ligand 9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Cytokine Activity Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding
	Biological Process	Respiratory Gaseous Exchange By Respiratory System Cellular Protein Metabolic Process	Chemotaxis Defense Response Inflammatory Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Neutrophil Chemotaxis Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Myoblast Fusion
Pathways		Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases		Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)	Blood protein levels ( 28240269) Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		36 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 PVR SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2	76 interacting genes: AMIGO1 AQP6 ATP1B4 BMF BSCL2 BTNL9 C16orf92 CCL11 CCL13 CCL2 CCL21 CCL26 CCL28 CCL5 CCR3 CD33 CHODL CLDN2 CLDN5 CLDN7 CLEC17A CLEC2D CLEC4E CLEC7A CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCR3 DPP4 EPGN EREG FBXO7 FCGR2A FFAR2 FNDC9 FUT7 GJB1 GORAB GPR42 IFNGR2 ITM2C KASH5 KIR2DL3 LDLRAD1 LEUTX LRRC25 LSMEM2 MR1 MTIF3 MUC1 NEMP1 PAX8 PF4 PPBP PTPN5 RHCG SFTPC SLC10A1 SLC39A1 SSMEM1 SUSD3 SYNE4 TM4SF18 TMED5 TMEM106C TMEM234 TMEM237 TMEM31 TMPRSS2 TNFSF14 TNFSF8 TSPAN18 XCL1
Entrez ID		6440	4283
HPRD ID		01520	03416
Ensembl ID		ENSG00000168484	ENSG00000138755
Uniprot IDs		A0A0A0MTC9 A0A0S2Z4Q0 E5RI64 P11686	Q07325
PDB IDs		2YAD
Enriched GO Terms of Interacting Partners?
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