SFTPC and ICAM3

Data Source:
BioGRID (two hybrid)

		SFTPC	ICAM3
Description		surfactant protein C	intercellular adhesion molecule 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Signaling Receptor Binding Integrin Binding Protein Binding
	Biological Process	Respiratory Gaseous Exchange By Respiratory System Cellular Protein Metabolic Process	Stimulatory C-type Lectin Receptor Signaling Pathway Phagocytosis Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion
Pathways		Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
Drugs
Diseases		Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)	Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		36 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 PVR SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2	20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16
Entrez ID		6440	3385
HPRD ID		01520	00889
Ensembl ID		ENSG00000168484	ENSG00000076662
Uniprot IDs		A0A0A0MTC9 A0A0S2Z4Q0 E5RI64 P11686	A0A024R7C1 K7ERN2 P32942
PDB IDs		2YAD	1T0P
Enriched GO Terms of Interacting Partners?
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