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UBE2K and CASP12
Data Source:
BioGRID
(enzymatic study)
UBE2K
CASP12
Description
ubiquitin conjugating enzyme E2 K
caspase 12 (gene/pseudogene)
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
Filopodium Tip
Cytoplasm
Endoplasmic Reticulum
IPAF Inflammasome Complex
NLRP3 Inflammasome Complex
AIM2 Inflammasome Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-threonine Phosphorylation
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Interferon-beta
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Protein K48-linked Ubiquitination
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Apoptotic Process
Regulation Of Inflammatory Response
Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Plasma amyloid beta peptide concentrations (ABx-40) (
24535457
)
Platelet count (
32888494
)
General risk tolerance (MTAG) (
30643258
)
Self-reported risk-taking behaviour (
30181555
)
Interacting Genes
95 interacting genes:
AMFR
ANAPC11
BARD1
BFAR
BIRC7
BIRC8
BRCA1
CASP12
CBLC
CCNC
CDC6
DDI1
DDX58
DIABLO
DTX3
DTX3L
DZIP3
EXOSC7
FZR1
HTT
ITCH
ITSN1
KRIT1
LRSAM1
MAP3K1
MARCHF3
MARCHF7
MDM2
MEOX2
MID1
MID2
MIPOL1
MKRN2
MKRN3
NEDD4L
NEDD8
NFKB1
NUB1
PAX6
PIAS4
PICK1
PJA1
PRKN
PRPF40A
PRRG4
RBCK1
RC3H2
REL
RING1
RLIM
RNF111
RNF114
RNF125
RNF138
RNF144A
RNF166
RNF167
RNF182
RNF183
RNF185
RNF2
RNF31
RNF32
RNF4
RNF41
RNF5
SDCBP
SENP1
SH3RF1
SIAH1
SMURF1
TP53
TRAF7
TRAIP
TRIM2
TRIM27
TRIM3
TRIM31
TRIM34
TRIM35
TRIM39
TRIM43
TRIM5
TRIM50
TRIM63
TSN
UBA1
UBB
UBE2I
UBOX5
UHRF2
USP1
WWP2
ZDHHC17
ZNF384
2 interacting genes:
CASP9
UBE2K
Entrez ID
3093
100506742
HPRD ID
04165
Ensembl ID
ENSG00000078140
ENSG00000204403
Uniprot IDs
B3KSH4
B4DIZ2
P61086
Q6UXS9
PDB IDs
1YLA
2O25
3E46
3F92
3K9O
3K9P
5DFL
6IF1
6JB6
6JB7
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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