UBE2K and SENP1

Data Source:
BioGRID (enzymatic study)

		UBE2K	SENP1
Description		ubiquitin conjugating enzyme E2 K	SUMO specific peptidase 1
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GO Annotations	Cellular Component	Nucleus Cytosol Filopodium Tip	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Sumoylation Protein Desumoylation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation	SUMO is proteolytically processed
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)	Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)
Interacting Genes		95 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM63 TSN UBA1 UBB UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384	22 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28
Entrez ID		3093	29843
HPRD ID		04165	07153
Ensembl ID		ENSG00000078140	ENSG00000079387
Uniprot IDs		B3KSH4 B4DIZ2 P61086	Q6N001 Q7Z3G1 Q9P0U3
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?
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