PKNOX2 and NUP54

Data Source:
BioGRID (two hybrid)

		PKNOX2	NUP54
Description		PBX/knotted 1 homeobox 2	nucleoporin 54
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Actin Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge	Nuclear Envelope Nuclear Membrane Host Cell Nuclear Pore Central Transport Channel
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Actin Monomer Binding Protein Binding Actin Filament Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Targeting NLS-bearing Protein Import Into Nucleus Nuclear Pore Organization Viral Process Protein Sumoylation Viral Transcription Protein Localization To Nuclear Inner Membrane Regulation Of Protein Import Into Nucleus Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways			ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21956439 21703634) Alcohol dependence symptom count ( 27151647) Alzheimer's disease (survival time) ( 25649651) Breast cancer (survival) ( 25890600) Dimensional psychopathology (Social) ( 29496196) Disease progression in age-related macular degeneration ( 29346644) Formal thought disorder in schizophrenia ( 22648509) Heel bone mineral density ( 30598549) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Prostate cancer ( 29892016) Schizophrenia ( 22688191) Serum uric acid levels in response to allopurinol in gout ( 25676789) Sleep duration ( 25469926) Substance dependence ( 21298047) Testicular germ cell tumor ( 28604728)	Hippocampal volume ( 29274321)
Interacting Genes		32 interacting genes: ARFIP2 C10orf88 C1orf216 CCDC116 CCDC185 CCDC196 CENPP CREBL2 CSTF2T CTTNBP2 CTTNBP2NL DDA1 ENKD1 FAM110B FHL2 HGS HOXB1 IQGAP1 MBD3 MCRS1 MYO15B NRIP1 NUP54 NUP58 PBX4 PICK1 SMARCD1 STK16 TRIB3 TSG101 USHBP1 VPS37C	46 interacting genes: AGR2 AP1B1 AP2B1 APC BPIFA1 C14orf119 C1orf109 C21orf91 CCDC85B CCHCR1 CDC23 CENPH DCTN3 DGCR6 EFHC1 EIF3F EXOC1 EXOC8 HAUS1 HAUS8 HGS HOMER1 IFT20 KPNA1 KPNB1 KRT15 KRT27 KRT33B NFKBID NR3C1 NUP62 NUTF2 OIP5 PKNOX2 SMYD3 SOHLH1 SPG21 SSR1 TACC3 TCHP TEKT1 TEX12 TPM3 TRIM54 VPS37C ZWINT
Entrez ID		63876	53371
HPRD ID		17857	06352
Ensembl ID		ENSG00000165495	ENSG00000138750
Uniprot IDs		Q96KN3	Q7Z3B4
PDB IDs			4JNU 4JNV 4JO7 4JO9 5IJN 5IJO
Enriched GO Terms of Interacting Partners?
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