NUP54 and KRT15

Data Source:
BioGRID (two hybrid)

		NUP54	KRT15
Description		nucleoporin 54	keratin 15
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Membrane Host Cell Nuclear Pore Central Transport Channel	Nucleus Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-containing Complex Binding	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding
	Biological Process	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Targeting NLS-bearing Protein Import Into Nucleus Nuclear Pore Organization Viral Process Protein Sumoylation Viral Transcription Protein Localization To Nuclear Inner Membrane Regulation Of Protein Import Into Nucleus Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Cytoskeleton Organization Epidermis Development Keratinization Cornification
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Hippocampal volume ( 29274321)
Interacting Genes		46 interacting genes: AGR2 AP1B1 AP2B1 APC BPIFA1 C14orf119 C1orf109 C21orf91 CCDC85B CCHCR1 CDC23 CENPH DCTN3 DGCR6 EFHC1 EIF3F EXOC1 EXOC8 HAUS1 HAUS8 HGS HOMER1 IFT20 KPNA1 KPNB1 KRT15 KRT27 KRT33B NFKBID NR3C1 NUP62 NUTF2 OIP5 PKNOX2 SMYD3 SOHLH1 SPG21 SSR1 TACC3 TCHP TEKT1 TEX12 TPM3 TRIM54 VPS37C ZWINT	145 interacting genes: ABI2 ABI3 ABLIM1 AMOT AMOTL2 ANKRD36BP1 APC ARC ARFIP2 ATP5PO BEX2 C1orf216 C2CD6 CALCOCO1 CARD9 CCDC120 CCDC185 CCDC187 CCDC87 CCHCR1 CCNB1IP1 CCNC CDK18 CEP57 COX5B CREB5 CYTH4 DEPP1 DES DEUP1 DGCR6L DTNB EFHC1 ENKD1 EPC1 EXOC8 FAM107A FAM110A GAS8 GFAP GLYCTK HAPLN2 HAUS1 HGS HMG20B HOXB6 IKBIP KANSL1 KDM1A KIAA0408 KIAA1217 KIFC3 KLC3 KLC4 KRT1 KRT18 KRT19 KRT2 KRT20 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LDOC1 LMO2 LMO4 LNX1 MAD2L1BP MBD3 MCM10 MORN3 MOS NEFL NIF3L1 NOC4L NUDT18 NUP54 OIP5 PCM1 PIK3R2 PKN1 PPP1R18 PRPF31 PRPH PSMA1 PSMB1 PSMC5 RAD51D RAMAC RCOR3 RHPN1 RIBC1 RIBC2 RNF6 RPP25 RSPH14 SGF29 SIRPA SMARCB1 SMARCD1 SMARCE1 SNAPIN SPG21 SSX2IP TBC1D21 TCHP TEKT4 TELO2 TIMM8A TLE5 TMSB4X TRIM42 TRIML2 TSG101 TTC23 TUBGCP4 TXLNA TXLNB TXNDC11 USHBP1 USP2 WAC ZC2HC1C ZFYVE26 ZGPAT ZNF417 ZNF576 ZNF638 ZNF688
Entrez ID		53371	3866
HPRD ID		06352	01009
Ensembl ID		ENSG00000138750	ENSG00000171346
Uniprot IDs		Q7Z3B4	B3KVF5 P19012
PDB IDs		4JNU 4JNV 4JO7 4JO9 5IJN 5IJO
Enriched GO Terms of Interacting Partners?
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