PKNOX2 and C1orf216

Data Source:
BioGRID (two hybrid)

		PKNOX2	C1orf216
Description		PBX/knotted 1 homeobox 2	chromosome 1 open reading frame 216
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Actin Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Actin Monomer Binding Protein Binding Actin Filament Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21956439 21703634) Alcohol dependence symptom count ( 27151647) Alzheimer's disease (survival time) ( 25649651) Breast cancer (survival) ( 25890600) Dimensional psychopathology (Social) ( 29496196) Disease progression in age-related macular degeneration ( 29346644) Formal thought disorder in schizophrenia ( 22648509) Heel bone mineral density ( 30598549) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Prostate cancer ( 29892016) Schizophrenia ( 22688191) Serum uric acid levels in response to allopurinol in gout ( 25676789) Sleep duration ( 25469926) Substance dependence ( 21298047) Testicular germ cell tumor ( 28604728)
Interacting Genes		32 interacting genes: ARFIP2 C10orf88 C1orf216 CCDC116 CCDC185 CCDC196 CENPP CREBL2 CSTF2T CTTNBP2 CTTNBP2NL DDA1 ENKD1 FAM110B FHL2 HGS HOXB1 IQGAP1 MBD3 MCRS1 MYO15B NRIP1 NUP54 NUP58 PBX4 PICK1 SMARCD1 STK16 TRIB3 TSG101 USHBP1 VPS37C	71 interacting genes: ABI2 AIMP2 AMOT BORCS6 CCDC136 CCDC158 CCDC197 CDR2 CDR2L CENPH CEP170P1 CEP55 CMC2 DES DMAP1 EIF3F EXOC5 FSD2 GGA1 HAP1 HAUS8 IFT20 KLHL20 KRT13 KRT15 KRT16 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT38 KRT39 KRT40 KRT75 KRT76 LRRC61 MAGEA6 MDFI MED4 MIS18A MLPH MRFAP1L1 MTUS2 MYRIP NECAB2 NMI NRBF2 NUP62 ODAD1 PKNOX2 PPP1R16A PSMC6 RALBP1 SERTAD3 SNW1 SYCE1L THAP1 TLE5 TMCO5A TPM1 TPM3 TRAF1 TRIM54 TRIM72 USHBP1 VPS52 WASHC1 ZDHHC17 ZNF620
Entrez ID		63876	127703
HPRD ID		17857	08798
Ensembl ID		ENSG00000165495	ENSG00000142686
Uniprot IDs		Q96KN3	Q8TAB5
PDB IDs
Enriched GO Terms of Interacting Partners?
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