Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CCL21 and PPBP
Data Source:
BioGRID
(pull down)
CCL21
PPBP
Description
C-C motif chemokine ligand 21
pro-platelet basic protein
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Region
Extracellular Space
Platelet Alpha Granule Lumen
Tertiary Granule Lumen
Molecular Function
Protein Binding
Chemokine Activity
CCR7 Chemokine Receptor Binding
Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Glucose Transmembrane Transporter Activity
Protein Binding
Chemokine Activity
Growth Factor Activity
CXCR Chemokine Receptor Binding
Biological Process
Establishment Of T Cell Polarity
Immunological Synapse Formation
Positive Regulation Of Cell-matrix Adhesion
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of T Cell Chemotaxis
Neutrophil Chemotaxis
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Ruffle Organization
Positive Regulation Of Cell Adhesion Mediated By Integrin
Response To Prostaglandin E
Mesangial Cell-matrix Adhesion
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Receptor-mediated Endocytosis
Cell Maturation
Positive Regulation Of Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Activation Of GTPase Activity
Dendritic Cell Dendrite Assembly
Negative Regulation Of Leukocyte Tethering Or Rolling
Cellular Response To Chemokine
Positive Regulation Of Cell Motility
Positive Regulation Of T Cell Migration
Positive Regulation Of Myeloid Dendritic Cell Chemotaxis
Negative Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Apoptotic Process
Platelet Degranulation
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Neutrophil Chemotaxis
Defense Response To Bacterium
Neutrophil Degranulation
Positive Regulation Of Cell Division
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Chemokine-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Glucose Transmembrane Transport
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Platelet degranulation
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation
Drugs
Ethanesulfonic acid
Copper
Diseases
GWAS
Autoimmune traits (pleiotropy) (
30572963
)
Blood protein levels (
30072576
)
Celiac disease (
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Rheumatoid arthritis (
30423114
18794853
30572963
23143596
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Metabolite levels (
22916037
)
Interacting Genes
32 interacting genes:
ACKR2
ACKR4
C3orf52
CCL13
CCL17
CCL23
CCL24
CCL26
CCL28
CCL5
CCR7
CTSD
CXCL10
CXCL11
CXCL12
CXCL13
CXCL14
CXCL17
CXCL2
CXCL9
GOT2
IGFBP7
LRRK1
OTP
PF4
PF4V1
PPBP
TMEM107
UBQLN4
VCAN
XCL1
XCL2
32 interacting genes:
CCL13
CCL21
CCL26
CCL28
CCL5
CCL8
CELF1
CMTM6
COPG1
COPS7A
COX17
CTSG
CXCL10
CXCL11
CXCL12
CXCL14
CXCL6
CXCL9
CXCR1
CXCR2
DMWD
EFNA1
MAPK6
MOB3B
NDUFB11
NR4A1
PLEKHJ1
PMAIP1
RAB10
RPS27
SCFD1
STRN4
Entrez ID
6366
5473
HPRD ID
04113
07171
Ensembl ID
ENSG00000137077
ENSG00000163736
Uniprot IDs
O00585
P02775
PDB IDs
2L4N
5EKI
1F9P
1NAP
1TVX
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?