PPBP and CELF1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PPBP	CELF1
Description		pro-platelet basic protein	CUGBP Elav-like family member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Tertiary Granule Lumen	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Membrane Perinucleolar Compartment Ribonucleoprotein Complex
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Translation Repressor Activity, MRNA Regulatory Element Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Pre-mRNA Binding BRE Binding
	Biological Process	Platelet Degranulation Inflammatory Response G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Glucose Transmembrane Transport	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing Germ Cell Development Negative Regulation Of Cell Population Proliferation Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death RNA Interference Posttranscriptional Gene Silencing Regulation Of RNA Splicing Regulation Of Inflammatory Response MRNA Destabilization
Pathways		Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs		Ethanesulfonic acid Copper
Diseases
GWAS		Metabolite levels ( 22916037)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Immature fraction of reticulocytes ( 32888494 27863252) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Metabolic syndrome ( 31589552) Neuroticism ( 29255261) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Platelet count ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Sleep duration (short sleep) ( 30846698) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	46 interacting genes: APP DMPK FUBP1 MIR106B MIR107 MIR10B MIR128-1 MIR138-2 MIR140 MIR143 MIR155 MIR15B MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR25 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I PPBP RALY TOM1L1
Entrez ID		5473	10658
HPRD ID		07171	03046
Ensembl ID		ENSG00000163736	ENSG00000149187
Uniprot IDs		P02775	G5EA30 Q92879
PDB IDs		1F9P 1NAP 1TVX	2CPZ 2DHS 2RQ4 2RQC 3NMR 3NNA 3NNC 3NNH
Enriched GO Terms of Interacting Partners?
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