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CCL21 and TMEM107
Data Source:
BioGRID
(two hybrid)
CCL21
TMEM107
Description
C-C motif chemokine ligand 21
transmembrane protein 107
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Integral Component Of Membrane
Ciliary Transition Zone
MKS Complex
Molecular Function
Protein Binding
Chemokine Activity
CCR7 Chemokine Receptor Binding
Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Molecular_function
Protein Binding
Biological Process
Establishment Of T Cell Polarity
Immunological Synapse Formation
Positive Regulation Of Cell-matrix Adhesion
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of T Cell Chemotaxis
Neutrophil Chemotaxis
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Ruffle Organization
Positive Regulation Of Cell Adhesion Mediated By Integrin
Response To Prostaglandin E
Mesangial Cell-matrix Adhesion
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Receptor-mediated Endocytosis
Cell Maturation
Positive Regulation Of Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Activation Of GTPase Activity
Dendritic Cell Dendrite Assembly
Negative Regulation Of Leukocyte Tethering Or Rolling
Cellular Response To Chemokine
Positive Regulation Of Cell Motility
Positive Regulation Of T Cell Migration
Positive Regulation Of Myeloid Dendritic Cell Chemotaxis
Negative Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Apoptotic Process
Detection Of Nodal Flow
Regulation Of Gene Expression
Neural Tube Patterning
Embryonic Digit Morphogenesis
Roof Of Mouth Development
Cilium Assembly
Craniofacial Suture Morphogenesis
Protein Localization To Ciliary Transition Zone
Non-motile Cilium Assembly
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Drugs
Diseases
GWAS
Autoimmune traits (pleiotropy) (
30572963
)
Blood protein levels (
30072576
)
Celiac disease (
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Rheumatoid arthritis (
30423114
18794853
30572963
23143596
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Diastolic blood pressure (
30224653
)
Urinary potassium excretion (
31409800
)
Interacting Genes
32 interacting genes:
ACKR2
ACKR4
C3orf52
CCL13
CCL17
CCL23
CCL24
CCL26
CCL28
CCL5
CCR7
CTSD
CXCL10
CXCL11
CXCL12
CXCL13
CXCL14
CXCL17
CXCL2
CXCL9
GOT2
IGFBP7
LRRK1
OTP
PF4
PF4V1
PPBP
TMEM107
UBQLN4
VCAN
XCL1
XCL2
44 interacting genes:
AQP3
AQP6
BIK
CCL21
CD40
CD79A
CLN8
CLSTN3
EBAG9
ERGIC3
EVI2B
FAM209A
FAM210B
FCER1G
GJA5
GJA8
GPX8
KCNA5
KCNJ6
LHFPL5
LMNA
MGST3
MS4A3
PDZK1IP1
PGRMC2
PIGP
SAR1A
SLC10A6
SLC30A2
SLC35C2
SLC39A2
SYT2
THAP4
TMEM106A
TMEM139
TMEM167B
TMEM234
TMEM237
TMEM31
TMEM51
TMEM52B
TMEM80
TMEM86B
VMA21
Entrez ID
6366
84314
HPRD ID
04113
14400
Ensembl ID
ENSG00000137077
ENSG00000179029
Uniprot IDs
O00585
Q6UX40
PDB IDs
2L4N
5EKI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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