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CCL21 and CXCL13
Data Source:
HPRD
(in vitro, in vivo)
CCL21
CXCL13
Description
C-C motif chemokine ligand 21
C-X-C motif chemokine ligand 13
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Region
Extracellular Space
Molecular Function
Protein Binding
Chemokine Activity
CCR7 Chemokine Receptor Binding
Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Chemokine Activity
Heparin Binding
Fibroblast Growth Factor Binding
CXCR5 Chemokine Receptor Binding
CCR10 Chemokine Receptor Binding
CXCR Chemokine Receptor Binding
Receptor Ligand Activity
CXCR3 Chemokine Receptor Binding
Biological Process
Establishment Of T Cell Polarity
Immunological Synapse Formation
Positive Regulation Of Cell-matrix Adhesion
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of T Cell Chemotaxis
Neutrophil Chemotaxis
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Ruffle Organization
Positive Regulation Of Cell Adhesion Mediated By Integrin
Response To Prostaglandin E
Mesangial Cell-matrix Adhesion
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Receptor-mediated Endocytosis
Cell Maturation
Positive Regulation Of Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Activation Of GTPase Activity
Dendritic Cell Dendrite Assembly
Negative Regulation Of Leukocyte Tethering Or Rolling
Cellular Response To Chemokine
Positive Regulation Of Cell Motility
Positive Regulation Of T Cell Migration
Positive Regulation Of Myeloid Dendritic Cell Chemotaxis
Negative Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Apoptotic Process
Germinal Center Formation
Lymphocyte Chemotaxis Across High Endothelial Venule
Chronic Inflammatory Response
Regulation Of Humoral Immune Response
Inflammatory Response
Immune Response
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Positive Regulation Of T Cell Chemotaxis
Neutrophil Chemotaxis
Positive Regulation Of Integrin Activation
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
B Cell Chemotaxis
Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Defense Response To Bacterium
Regulation Of Angiogenesis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Chemokine-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Activation Of GTPase Activity
Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Chemokine receptors bind chemokines
G alpha (i) signalling events
Drugs
Diseases
GWAS
Autoimmune traits (pleiotropy) (
30572963
)
Blood protein levels (
30072576
)
Celiac disease (
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Rheumatoid arthritis (
30423114
18794853
30572963
23143596
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Cardiac Troponin-T levels (
23247143
)
Diffusing capacity of carbon monoxide (
30694715
)
Tonsillectomy (
27182965
28928442
)
Waist circumference adjusted for body mass index (
28552196
)
Interacting Genes
32 interacting genes:
ACKR2
ACKR4
C3orf52
CCL13
CCL17
CCL23
CCL24
CCL26
CCL28
CCL5
CCR7
CTSD
CXCL10
CXCL11
CXCL12
CXCL13
CXCL14
CXCL17
CXCL2
CXCL9
GOT2
IGFBP7
LRRK1
OTP
PF4
PF4V1
PPBP
TMEM107
UBQLN4
VCAN
XCL1
XCL2
11 interacting genes:
ACKR4
CCL19
CCL21
CCL28
CCL4L1
CCR10
CXCR3
CXCR5
EEF1G
FGF2
PF4V1
Entrez ID
6366
10563
HPRD ID
04113
05513
Ensembl ID
ENSG00000137077
ENSG00000156234
Uniprot IDs
O00585
O43927
Q53X90
PDB IDs
2L4N
5EKI
5CBA
5CBE
6VGJ
7JNY
Enriched GO Terms of Interacting Partners
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