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CCL21 and CCL26
Data Source:
BioGRID
(pull down)
CCL21
CCL26
Description
C-C motif chemokine ligand 21
C-C motif chemokine ligand 26
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Space
Molecular Function
Protein Binding
Chemokine Activity
CCR7 Chemokine Receptor Binding
Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Protein Binding
Chemokine Activity
CCR3 Chemokine Receptor Binding
Receptor Ligand Activity
CCR Chemokine Receptor Binding
Biological Process
Establishment Of T Cell Polarity
Immunological Synapse Formation
Positive Regulation Of Cell-matrix Adhesion
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of T Cell Chemotaxis
Neutrophil Chemotaxis
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Ruffle Organization
Positive Regulation Of Cell Adhesion Mediated By Integrin
Response To Prostaglandin E
Mesangial Cell-matrix Adhesion
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Receptor-mediated Endocytosis
Cell Maturation
Positive Regulation Of Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Activation Of GTPase Activity
Dendritic Cell Dendrite Assembly
Negative Regulation Of Leukocyte Tethering Or Rolling
Cellular Response To Chemokine
Positive Regulation Of Cell Motility
Positive Regulation Of T Cell Migration
Positive Regulation Of Myeloid Dendritic Cell Chemotaxis
Negative Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Apoptotic Process
Positive Regulation Of Endothelial Cell Proliferation
Monocyte Chemotaxis
Chemotaxis
Inflammatory Response
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
T Cell Chemotaxis
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of GTPase Activity
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Drugs
Diseases
GWAS
Autoimmune traits (pleiotropy) (
30572963
)
Blood protein levels (
30072576
)
Celiac disease (
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Rheumatoid arthritis (
30423114
18794853
30572963
23143596
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Carotid plaque burden (
28282560
)
Response to cognitive-behavioural therapy in major depressive disorder (
31123309
)
Interacting Genes
32 interacting genes:
ACKR2
ACKR4
C3orf52
CCL13
CCL17
CCL23
CCL24
CCL26
CCL28
CCL5
CCR7
CTSD
CXCL10
CXCL11
CXCL12
CXCL13
CXCL14
CXCL17
CXCL2
CXCL9
GOT2
IGFBP7
LRRK1
OTP
PF4
PF4V1
PPBP
TMEM107
UBQLN4
VCAN
XCL1
XCL2
24 interacting genes:
APP
C3orf52
CCL11
CCL13
CCL17
CCL2
CCL21
CCL28
CCL5
CCL8
CCR1
CCR3
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL9
PAX6
PF4
PF4V1
PPBP
XCL1
XCL2
Entrez ID
6366
10344
HPRD ID
04113
05262
Ensembl ID
ENSG00000137077
ENSG00000006606
Uniprot IDs
O00585
Q9Y258
PDB IDs
2L4N
5EKI
1G2S
1G2T
Enriched GO Terms of Interacting Partners
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