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PXN and PAK1
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
PXN
PAK1
Description
paxillin
p21 (RAC1) activated kinase 1
Image
GO Annotations
Cellular Component
Stress Fiber
Cytosol
Microtubule Associated Complex
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Lamellipodium
Ruffle
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Z Disc
Lamellipodium
Axon
Dendrite
Nuclear Membrane
Ruffle Membrane
Protein-containing Complex
Molecular Function
Transcription Coregulator Activity
Protein Binding
Beta-catenin Binding
Vinculin Binding
Protein Phosphatase Binding
Neuropilin Binding
Metal Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Protein Kinase Binding
Small GTPase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Regulation Of Transcription, DNA-templated
Muscle Contraction
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Signal Complex Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Reactive Oxygen Species
Endothelial Cell Migration
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
MAPK Cascade
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Chromatin Remodeling
Protein Phosphorylation
Exocytosis
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Fibroblast Migration
Cell Migration
Cerebellum Development
Establishment Of Cell Polarity
Positive Regulation Of Cell Migration
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Microtubule Polymerization
T Cell Costimulation
Actin Cytoskeleton Reorganization
Activation Of Protein Kinase Activity
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Axon Extension
Positive Regulation Of Insulin Receptor Signaling Pathway
Protein Autophosphorylation
Hepatocyte Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
Regulation Of Axonogenesis
T Cell Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
FCERI mediated MAPK activation
DSCAM interactions
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
Signal transduction by L1
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PKNs
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
G beta:gamma signalling through CDC42
Drugs
Fostamatinib
Diseases
GWAS
Bipolar disorder (
31043756
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
29403010
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Tourette syndrome (
30818990
)
Interacting Genes
87 interacting genes:
ABL1
ACO1
AHCY
AR
ARHGEF7
ASAP1
ASAP2
BCAR1
BCL2
BLK
CASP3
CEACAM1
CLTC
CREB3L2
CRK
CRKL
CSK
DGUOK
DPY30
EPHB1
FYN
GART
GIT1
GIT2
GRB2
GSK3A
GSK3B
GSN
HDAC6
ILK
ITGA4
ITGA6
ITGA9
ITGAV
ITGB1
ITGB3
LCK
LIMK1
LMO1
LMO3
MAPK1
MAPK3
MAPK8
MATK
NCK1
NEDD9
NF2
PABPC1
PAK1
PAK3
PARVA
PDPK1
PKD1
PLEKHH2
PLEKHN1
POLR1D
PPP2CA
PPP2R5C
PTEN
PTK2
PTK2B
PTPN11
PTPN12
PTPRH
RASA1
REPS2
RHOU
RNF5
SDC4
SELE
SH3RF1
SORBS1
SRC
SYK
TCEANC
TGM2
TLN1
TRIM15
TRIP6
TUBA1B
TUBA3C
TUBA8
TUBG1
TUBG2
VCL
WHRN
YES1
85 interacting genes:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BMPR1B
BMX
BRSK1
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CPLANE1
CSNK2A1
CSNK2A2
DSCAM
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
H3C1
H4C1
HACE1
HGS
HSP90AA1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1A
PPM1F
PPP1CA
PPP2CA
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
Entrez ID
5829
5058
HPRD ID
03937
03995
Ensembl ID
ENSG00000089159
ENSG00000149269
Uniprot IDs
A0A140VJQ8
P49023
A0A024R5P0
Q13153
PDB IDs
1KKY
1KL0
1OW6
1OW7
1OW8
2K2R
2O9V
2VZD
2VZG
2VZI
3GM1
3PY7
3RQE
3RQF
3RQG
3U3F
4EDN
4R32
4XGZ
4XH2
5UWH
6IUI
6PW8
6U4M
6U4N
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
4O0R
4O0T
4P90
4ZJI
4ZJJ
4ZLO
4ZY4
4ZY5
4ZY6
5DEW
5DEY
5DFP
5IME
5KBQ
5KBR
6B16
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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