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PXN and HDAC6
Data Source:
BioGRID
(imaging technique, fluorescent resonance energy transfer, affinity chromatography technology)
PXN
HDAC6
Description
paxillin
histone deacetylase 6
Image
GO Annotations
Cellular Component
Stress Fiber
Cytosol
Microtubule Associated Complex
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Lamellipodium
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Multivesicular Body
Cytosol
Microtubule
Microtubule Associated Complex
Caveola
Inclusion Body
Aggresome
Dynein Complex
Axon
Dendrite
Cell Leading Edge
Perikaryon
Perinuclear Region Of Cytoplasm
Molecular Function
Transcription Coregulator Activity
Protein Binding
Beta-catenin Binding
Vinculin Binding
Protein Phosphatase Binding
Neuropilin Binding
Metal Ion Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Corepressor Binding
Actin Binding
Histone Deacetylase Activity
Protein Binding
Beta-catenin Binding
Microtubule Binding
Zinc Ion Binding
Enzyme Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
Tubulin Deacetylase Activity
Alpha-tubulin Binding
Ubiquitin Binding
Acetylspermidine Deacetylase Activity
Tau Protein Binding
Beta-tubulin Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Dynein Complex Binding
Biological Process
Regulation Of Transcription, DNA-templated
Muscle Contraction
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Signal Complex Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Reactive Oxygen Species
Endothelial Cell Migration
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
Protein Polyubiquitination
Protein Deacetylation
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Intracellular Protein Transport
Autophagy
Negative Regulation Of Microtubule Depolymerization
Regulation Of Autophagy
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of Macroautophagy
Histone Deacetylation
Negative Regulation Of Protein-containing Complex Assembly
Regulation Of Protein Stability
Protein Destabilization
Lysosome Localization
Protein-containing Complex Disassembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Peptidyl-lysine Deacetylation
Cellular Response To Topologically Incorrect Protein
Regulation Of Gene Expression, Epigenetic
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Fat Cell Differentiation
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Collateral Sprouting
Negative Regulation Of Oxidoreductase Activity
Mitochondrion Localization
Response To Misfolded Protein
Cilium Assembly
Regulation Of Microtubule-based Movement
Regulation Of Androgen Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Regulation Of Establishment Of Protein Localization
Cellular Response To Hydrogen Peroxide
Aggresome Assembly
Polyubiquitinated Misfolded Protein Transport
Hsp90 Deacetylation
Response To Growth Factor
Histone H3 Deacetylation
Cellular Response To Misfolded Protein
Tubulin Deacetylation
Polyamine Deacetylation
Spermidine Deacetylation
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Signaling Receptor Activity
Pathways
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HSF1 activation
Notch-HLH transcription pathway
Cilium Assembly
Transcriptional regulation by RUNX2
RUNX2 regulates osteoblast differentiation
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Aggrephagy
Drugs
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Bufexamac
Diseases
GWAS
Bipolar disorder (
31043756
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
29403010
)
Interacting Genes
87 interacting genes:
ABL1
ACO1
AHCY
AR
ARHGEF7
ASAP1
ASAP2
BCAR1
BCL2
BLK
CASP3
CEACAM1
CLTC
CREB3L2
CRK
CRKL
CSK
DGUOK
DPY30
EPHB1
FYN
GART
GIT1
GIT2
GRB2
GSK3A
GSK3B
GSN
HDAC6
ILK
ITGA4
ITGA6
ITGA9
ITGAV
ITGB1
ITGB3
LCK
LIMK1
LMO1
LMO3
MAPK1
MAPK3
MAPK8
MATK
NCK1
NEDD9
NF2
PABPC1
PAK1
PAK3
PARVA
PDPK1
PKD1
PLEKHH2
PLEKHN1
POLR1D
PPP2CA
PPP2R5C
PTEN
PTK2
PTK2B
PTPN11
PTPN12
PTPRH
RASA1
REPS2
RHOU
RNF5
SDC4
SELE
SH3RF1
SORBS1
SRC
SYK
TCEANC
TGM2
TLN1
TRIM15
TRIP6
TUBA1B
TUBA3C
TUBA8
TUBG1
TUBG2
VCL
WHRN
YES1
83 interacting genes:
ADRB2
APOBEC3G
ARHGDIA
ATF3
ATXN3
AURKA
BBS10
BCL3
BCOR
BRMS1
CDKN1A
CEP70
CSNK2A2
CTTN
CYLD
DYNLL2
EGFR
EP300
ERBB2
ERBB3
ERBB4
FBP1
FBXO11
FNTA
FNTB
GRK2
H3C1
H4-16
HDAC11
HES1
HSP90AA1
HTATIP2
HTATSF1
ISG15
JDP2
KPNA1
LCOR
LPXN
MAPK1
MAPK3
MAPT
MLH1
MSH2
NACAD
NASP
NR0B2
NR3C1
PLAA
POLA2
POLDIP2
POLR1B
PPP1CC
PRDX4
PRKCZ
PRKN
PROM1
PTOV1
PXN
RELB
RNF31
RUNX2
SEPTIN7
SIRT2
SYK
TPPP
TRIM50
TUBA1A
TUBA1B
TUBA4A
TUBB
TUBB2A
TUBB2B
UBB
UBC
UBE2D1
UBE2D3
UBE2E1
UBE2H
VCP
VKORC1
YWHAZ
ZBTB16
ZNF205
Entrez ID
5829
10013
HPRD ID
03937
02228
Ensembl ID
ENSG00000089159
ENSG00000094631
Uniprot IDs
A0A140VJQ8
P49023
A0A024QZ26
B4DZH6
Q9BRX7
Q9NSW6
Q9UBN7
PDB IDs
1KKY
1KL0
1OW6
1OW7
1OW8
2K2R
2O9V
2VZD
2VZG
2VZI
3GM1
3PY7
3RQE
3RQF
3RQG
3U3F
4EDN
4R32
4XGZ
4XH2
5UWH
6IUI
6PW8
6U4M
6U4N
3C5K
3GV4
3PHD
5B8D
5EDU
5KH3
5KH7
5KH9
5WBN
5WPB
6CE6
6CE8
6CEA
6CEC
6CED
6CEE
6CEF
Enriched GO Terms of Interacting Partners
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