PAK1 and ARHGEF2

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		PAK1	ARHGEF2
Description		p21 (RAC1) activated kinase 1	Rho/Rac guanine nucleotide exchange factor 2
Image
GO Annotations	Cellular Component	Ruffle Nucleoplasm Chromosome Cytoplasm Cytosol Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Lamellipodium Axon Dendrite Nuclear Membrane Ruffle Membrane Protein-containing Complex	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Bicellular Tight Junction Focal Adhesion Cytoplasmic Vesicle Vesicle Ruffle Membrane Protein-containing Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding Small GTPase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Transcription Factor Binding Zinc Ion Binding Small GTPase Binding
	Biological Process	MAPK Cascade Response To Hypoxia Positive Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Protein Phosphorylation Exocytosis Apoptotic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Fibroblast Migration Cell Migration Cerebellum Development Establishment Of Cell Polarity Positive Regulation Of Cell Migration Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Microtubule Polymerization T Cell Costimulation Actin Cytoskeleton Reorganization Activation Of Protein Kinase Activity Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Positive Regulation Of JUN Kinase Activity Positive Regulation Of Axon Extension Positive Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Cell Morphogenesis Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Cell Cycle G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Asymmetric Neuroblast Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Neuron Migration
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation DSCAM interactions CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs		Fostamatinib
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neuritic plaque ( 31497858) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		85 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	13 interacting genes: CGN MARK3 NFKBID PAK1 PTPRF RAC1 RHOA RPP25L RRAS2 YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		5058	9181
HPRD ID		03995	10458
Ensembl ID		ENSG00000149269	ENSG00000116584
Uniprot IDs		A0A024R5P0 Q13153	A0A5F9ZI21 Q92974
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16	5EFX
Enriched GO Terms of Interacting Partners?
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