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PAK1 and RAF1
Data Source:
BioGRID
(affinity chromatography technology, pull down, enzymatic study)
HPRD
(in vitro, in vivo)
PAK1
RAF1
Description
p21 (RAC1) activated kinase 1
Raf-1 proto-oncogene, serine/threonine kinase
Image
GO Annotations
Cellular Component
Ruffle
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Z Disc
Lamellipodium
Axon
Dendrite
Nuclear Membrane
Ruffle Membrane
Protein-containing Complex
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Nuclear Speck
Pseudopodium
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Protein Kinase Binding
Small GTPase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Adenylate Cyclase Binding
Adenylate Cyclase Activator Activity
Enzyme Binding
Small GTPase Binding
Mitogen-activated Protein Kinase Kinase Binding
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
MAPK Cascade
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Chromatin Remodeling
Protein Phosphorylation
Exocytosis
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Fibroblast Migration
Cell Migration
Cerebellum Development
Establishment Of Cell Polarity
Positive Regulation Of Cell Migration
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Microtubule Polymerization
T Cell Costimulation
Actin Cytoskeleton Reorganization
Activation Of Protein Kinase Activity
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Axon Extension
Positive Regulation Of Insulin Receptor Signaling Pathway
Protein Autophosphorylation
Hepatocyte Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
Regulation Of Axonogenesis
T Cell Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
MAPK Cascade
Activation Of MAPKK Activity
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Signal Transduction
Activation Of Adenylate Cyclase Activity
Heart Development
Negative Regulation Of Cell Population Proliferation
Cell Differentiation
Platelet Activation
Thyroid Gland Development
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Ion Transmembrane Transport
Somatic Stem Cell Population Maintenance
Regulation Of Rho Protein Signal Transduction
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Muscle Stretch
Wound Healing
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Intermediate Filament Cytoskeleton Organization
Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Neurotrophin TRK Receptor Signaling Pathway
Thymus Development
Face Development
Death-inducing Signaling Complex Assembly
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Cell Motility
Pathways
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
FCERI mediated MAPK activation
DSCAM interactions
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
Signal transduction by L1
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PKNs
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
G beta:gamma signalling through CDC42
Stimuli-sensing channels
Rap1 signalling
GP1b-IX-V activation signalling
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by MRAS-complex mutants
Drugs
Fostamatinib
Sorafenib
LErafAON
XL281
iCo-007
Cholecystokinin
Regorafenib
Dabrafenib
Fostamatinib
Diseases
GWAS
Post bronchodilator FEV1/FVC ratio (
26634245
)
Tourette syndrome (
30818990
)
Asthma (
32296059
)
Cardiac hypertrophy (
21348951
)
Carotid intima media thickness x smoking interaction (
32117412
)
Cholesterol, total (
24097068
20686565
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
HDL cholesterol levels (
32203549
)
Total cholesterol levels (
28334899
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
85 interacting genes:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BMPR1B
BMX
BRSK1
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CPLANE1
CSNK2A1
CSNK2A2
DSCAM
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
H3C1
H4C1
HACE1
HGS
HSP90AA1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1A
PPM1F
PPP1CA
PPP2CA
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
160 interacting genes:
ABCB5
ADCY6
AGTR1
AKT1
AR
ARNT
ARRB2
BAD
BAG1
BCL2
BCL2L1
BCL6
BECN1
BIRC2
BIRC3
BRAF
CASZ1
CBLC
CCND2
CCT3
CD44
CDC25A
CDC37
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CFLAR
CNKSR1
COPS3
COPS7A
CPS1
DCAF8
DMPK
EFEMP1
EGFR
EPHA2
ERBB2
ERBIN
FGFR4
FYCO1
FYN
GLIS2
GNB2
GNG4
GRB10
GRM1
HERC1
HGF
HRAS
HSP90AA1
HSPA4
HSPA8
IL2RB
INSR
INTS10
JAK1
JAK2
KEAP1
KRAS
KRT18
KRT8
KSR1
KSR2
LATS2
LCK
LOX
LRPAP1
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MAP2K6
MAP3K1
MAP3K5
MAPK1
MAPK3
MAPK7
MAPK8
MAPK8IP3
MBP
MET
MRAS
MRC2
MYBPC1
MYC
NEDD4
NF1
NF2
NPLOC4
NR3C1
NRAS
NUDT14
OIP5
PACSIN3
PAK1
PAK2
PAK3
PBK
PDGFRA
PDGFRB
PDLIM2
PEBP1
PEBP4
PEX5L
PHB
PHKA2
PIN1
PKM
PPP1CC
PPP2CB
PRKAA1
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCE
PRKCZ
PRKG1
PRPF6
PURA
RANBP9
RAP1A
RAP2A
RASD2
RASSF1
RB1
RBBP8
RBL2
RFXANK
RHEB
RRAS
RRAS2
RSU1
SHOC2
SPRY2
SPRY4
SRC
STK26
STK3
STUB1
TBXA2R
TEAD2
TERT
TIMM50
TMEM70
TSC22D3
UBE2D2
UBE2L3
VAV1
VDAC1
XIAP
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
YY1
Entrez ID
5058
5894
HPRD ID
03995
01265
Ensembl ID
ENSG00000149269
ENSG00000132155
Uniprot IDs
A0A024R5P0
Q13153
A0A0S2Z4L5
L7RRS6
P04049
PDB IDs
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
4O0R
4O0T
4P90
4ZJI
4ZJJ
4ZLO
4ZY4
4ZY5
4ZY6
5DEW
5DEY
5DFP
5IME
5KBQ
5KBR
6B16
1C1Y
1FAQ
1FAR
1GUA
1RFA
3CU8
3IQJ
3IQU
3IQV
3KUC
3KUD
3NKX
3O8I
3OMV
4FJ3
4G0N
4G3X
4IEA
4IHL
6NTC
6NTD
6PTS
6PTW
7JHP
Enriched GO Terms of Interacting Partners
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