PAK1 and FRS2

Data Source:
HPRD (in vitro)

		PAK1	FRS2
Description		p21 (RAC1) activated kinase 1	fibroblast growth factor receptor substrate 2
Image
GO Annotations	Cellular Component	Ruffle Nucleoplasm Chromosome Cytoplasm Cytosol Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Lamellipodium Axon Dendrite Nuclear Membrane Ruffle Membrane Protein-containing Complex	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Endomembrane System Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding Small GTPase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phosphatase Activator Activity
	Biological Process	MAPK Cascade Response To Hypoxia Positive Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Protein Phosphorylation Exocytosis Apoptotic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Fibroblast Migration Cell Migration Cerebellum Development Establishment Of Cell Polarity Positive Regulation Of Cell Migration Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Microtubule Polymerization T Cell Costimulation Actin Cytoskeleton Reorganization Activation Of Protein Kinase Activity Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Positive Regulation Of JUN Kinase Activity Positive Regulation Of Axon Extension Positive Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Gastrulation With Mouth Forming Second Organ Induction Ventricular Septum Development Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuroblast Proliferation Axon Guidance Fibroblast Growth Factor Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Development Regulation Of Apoptotic Process Optic Placode Formation Involved In Camera-type Eye Formation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation DSCAM interactions CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42	PI3K Cascade PIP3 activates AKT signaling Frs2-mediated activation Frs2-mediated activation Constitutive Signaling by Aberrant PI3K in Cancer PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3
Drugs		Fostamatinib
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Complete remission in asthma ( 29786918) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) Logical memory (delayed recall) in normal cognition ( 29274321) Microalbuminuria ( 31511532) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Thyroid stimulating hormone levels ( 32769997) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		85 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	28 interacting genes: BECN1 CBL CDK3 CRK DDR1 FGFR1 GAB1 GRB2 INSR KDR MAPK1 MAPK3 NCK1 NTRK1 NTRK2 NTRK3 PAK1 PIN1 PRKCI PRKCZ PTPN11 PTPRF RET RND1 RPS6 SOS1 SRC YJU2
Entrez ID		5058	10818
HPRD ID		03995	06372
Ensembl ID		ENSG00000149269	ENSG00000166225
Uniprot IDs		A0A024R5P0 Q13153	L7RTG7 Q8WU20
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16	1XR0 2MFQ
Enriched GO Terms of Interacting Partners?
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