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PXN and TGM2
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
PXN
TGM2
Description
paxillin
transglutaminase 2
Image
GO Annotations
Cellular Component
Stress Fiber
Cytosol
Microtubule Associated Complex
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Lamellipodium
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Focal Adhesion
Intrinsic Component Of Plasma Membrane
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Transcription Coregulator Activity
Protein Binding
Beta-catenin Binding
Vinculin Binding
Protein Phosphatase Binding
Neuropilin Binding
Metal Ion Binding
Protein-glutamine Gamma-glutamyltransferase Activity
Protein Binding
GTP Binding
Protein Domain Specific Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
Regulation Of Transcription, DNA-templated
Muscle Contraction
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Signal Complex Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Reactive Oxygen Species
Endothelial Cell Migration
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
Blood Vessel Remodeling
Peptide Cross-linking
Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine
Protein Phosphopantetheinylation
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Apoptotic Cell Clearance
Positive Regulation Of Cell Adhesion
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Branching Involved In Salivary Gland Morphogenesis
Salivary Gland Cavitation
Pathways
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Guanosine-5'-Diphosphate
Hexylresorcinol
Diseases
GWAS
Bipolar disorder (
31043756
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
29403010
)
Interacting Genes
87 interacting genes:
ABL1
ACO1
AHCY
AR
ARHGEF7
ASAP1
ASAP2
BCAR1
BCL2
BLK
CASP3
CEACAM1
CLTC
CREB3L2
CRK
CRKL
CSK
DGUOK
DPY30
EPHB1
FYN
GART
GIT1
GIT2
GRB2
GSK3A
GSK3B
GSN
HDAC6
ILK
ITGA4
ITGA6
ITGA9
ITGAV
ITGB1
ITGB3
LCK
LIMK1
LMO1
LMO3
MAPK1
MAPK3
MAPK8
MATK
NCK1
NEDD9
NF2
PABPC1
PAK1
PAK3
PARVA
PDPK1
PKD1
PLEKHH2
PLEKHN1
POLR1D
PPP2CA
PPP2R5C
PTEN
PTK2
PTK2B
PTPN11
PTPN12
PTPRH
RASA1
REPS2
RHOU
RNF5
SDC4
SELE
SH3RF1
SORBS1
SRC
SYK
TCEANC
TGM2
TLN1
TRIM15
TRIP6
TUBA1B
TUBA3C
TUBA8
TUBG1
TUBG2
VCL
WHRN
YES1
59 interacting genes:
A2M
ABCA1
ACTB
ADAR
ALDOA
ANKRD28
ANXA1
APP
ARNT
ATF4
BNIP3
C3
CASP3
CBL
CERT1
CSNK2A2
EIF5A
FN1
FNTA
GCGR
GRN
GSTP1
H2BC21
H2BC8
HNRNPF
HNRNPUL1
HP
HSPA1A
HSPA1B
HSPA8
HTT
ITGB1
ITGB3
KPNA3
KPNA4
LACRT
LTBP1
MAP3K12
PAK1
PINK1
PLCD1
PPHLN1
PXN
RB1
RELA
RHOA
S100A7
SERPINF2
SERTAD1
SIPA1L2
SLC7A9
SMAD2
SMAD3
SPARC
TAB2
TMEM176A
TMSB4X
TUBB
ZNF512B
Entrez ID
5829
7052
HPRD ID
03937
01825
Ensembl ID
ENSG00000089159
ENSG00000198959
Uniprot IDs
A0A140VJQ8
P49023
B4DIT7
B4DTN7
P21980
V9HWG3
PDB IDs
1KKY
1KL0
1OW6
1OW7
1OW8
2K2R
2O9V
2VZD
2VZG
2VZI
3GM1
3PY7
3RQE
3RQF
3RQG
3U3F
4EDN
4R32
4XGZ
4XH2
5UWH
6IUI
6PW8
6U4M
6U4N
1FAU
1KV3
2Q3Z
3LY6
3S3J
3S3P
3S3S
4PYG
6A8P
Enriched GO Terms of Interacting Partners
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