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PXN and PAK3
Data Source:
HPRD
(in vitro)
PXN
PAK3
Description
paxillin
p21 (RAC1) activated kinase 3
Image
GO Annotations
Cellular Component
Stress Fiber
Cytosol
Microtubule Associated Complex
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Lamellipodium
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Postsynaptic Density
Glutamatergic Synapse
Molecular Function
Transcription Coregulator Activity
Protein Binding
Beta-catenin Binding
Vinculin Binding
Protein Phosphatase Binding
Neuropilin Binding
Metal Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
SH3 Domain Binding
Small GTPase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Regulation Of Transcription, DNA-templated
Muscle Contraction
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Signal Complex Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Reactive Oxygen Species
Endothelial Cell Migration
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
MAPK Cascade
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Axonogenesis
Positive Regulation Of Fibroblast Migration
Dendrite Development
Regulation Of Actin Filament Polymerization
Stress-activated Protein Kinase Signaling Cascade
T Cell Costimulation
Activation Of Protein Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Ephrin Receptor Signaling Pathway
Regulation Of Axonogenesis
Synapse Organization
T Cell Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Morphogenesis
Cellular Response To Organic Cyclic Compound
Positive Regulation Of DNA Biosynthetic Process
Pathways
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Generation of second messenger molecules
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Drugs
Fostamatinib
Diseases
Non-syndromic X-linked mental retardation
GWAS
Bipolar disorder (
31043756
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
29403010
)
Interacting Genes
87 interacting genes:
ABL1
ACO1
AHCY
AR
ARHGEF7
ASAP1
ASAP2
BCAR1
BCL2
BLK
CASP3
CEACAM1
CLTC
CREB3L2
CRK
CRKL
CSK
DGUOK
DPY30
EPHB1
FYN
GART
GIT1
GIT2
GRB2
GSK3A
GSK3B
GSN
HDAC6
ILK
ITGA4
ITGA6
ITGA9
ITGAV
ITGB1
ITGB3
LCK
LIMK1
LMO1
LMO3
MAPK1
MAPK3
MAPK8
MATK
NCK1
NEDD9
NF2
PABPC1
PAK1
PAK3
PARVA
PDPK1
PKD1
PLEKHH2
PLEKHN1
POLR1D
PPP2CA
PPP2R5C
PTEN
PTK2
PTK2B
PTPN11
PTPN12
PTPRH
RASA1
REPS2
RHOU
RNF5
SDC4
SELE
SH3RF1
SORBS1
SRC
SYK
TCEANC
TGM2
TLN1
TRIM15
TRIP6
TUBA1B
TUBA3C
TUBA8
TUBG1
TUBG2
VCL
WHRN
YES1
13 interacting genes:
ARHGEF6
ARHGEF7
CDC42
GIT1
GIT2
MYO6
NCK1
PXN
RAC1
RAF1
RHOJ
SNCA
SYN1
Entrez ID
5829
5063
HPRD ID
03937
02142
Ensembl ID
ENSG00000089159
ENSG00000077264
Uniprot IDs
A0A140VJQ8
P49023
B2RCU6
O75914
PDB IDs
1KKY
1KL0
1OW6
1OW7
1OW8
2K2R
2O9V
2VZD
2VZG
2VZI
3GM1
3PY7
3RQE
3RQF
3RQG
3U3F
4EDN
4R32
4XGZ
4XH2
5UWH
6IUI
6PW8
6U4M
6U4N
6FD3
Enriched GO Terms of Interacting Partners
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