PXN and MATK

Data Source:
HPRD (in vitro)

		PXN	MATK
Description		paxillin	megakaryocyte-associated tyrosine kinase
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GO Annotations	Cellular Component	Stress Fiber Cytosol Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium	Cytosol Membrane
	Molecular Function	Transcription Coregulator Activity Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Transcription, DNA-templated Muscle Contraction Cell Adhesion Cell-matrix Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation ERBB2 Signaling Pathway
Pathways		GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Downregulation of ERBB2 signaling
Drugs			Fostamatinib
Diseases
GWAS		Bipolar disorder ( 31043756) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)	Obesity-related traits ( 23251661)
Interacting Genes		87 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 PLEKHH2 PLEKHN1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN YES1	24 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC
Entrez ID		5829	4145
HPRD ID		03937	02496
Ensembl ID		ENSG00000089159	ENSG00000007264
Uniprot IDs		A0A140VJQ8 P49023	F1T0G6 P42679
PDB IDs		1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N	1JWO 1X6G 3US4
Enriched GO Terms of Interacting Partners?
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