SCIN and ACTC1

Data Source:
HPRD (in vivo)

		SCIN	ACTC1
Description		scinderin	actin alpha cardiac muscle 1
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Plasma Membrane Cell Cortex Actin Cytoskeleton Cell Junction Protein-containing Complex Cell Projection Extracellular Exosome	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Phosphatidylserine Binding Actin Binding Calcium Ion Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Central Nervous System Development Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Calcium-ion Regulated Exocytosis Cell Projection Assembly Regulation Of Chondrocyte Differentiation Sequestering Of Actin Monomers Positive Regulation Of Apoptotic Process Actin Nucleation Positive Regulation Of Megakaryocyte Differentiation Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Secretion Positive Regulation Of Actin Nucleation Actin Filament Capping	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration
Pathways			Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Height ( 31562340) Metabolite levels ( 23823483) Small cell lung carcinoma ( 28604730)	Axial length ( 24144296) Refractive error ( 32231278 20835239)
Interacting Genes		3 interacting genes: ACTA1 ACTC1 ACTG1	41 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		85477	70
HPRD ID		11539	00015
Ensembl ID		ENSG00000006747	ENSG00000159251
Uniprot IDs		Q9Y6U3	B3KPP5 P68032
PDB IDs		3FG6 5A1K 5A1M
Enriched GO Terms of Interacting Partners?
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