ABHD6 and FIS1

Data Source:
BioGRID (two hybrid)

		ABHD6	FIS1
Description		abhydrolase domain containing 6, acylglycerol lipase	fission, mitochondrial 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Mitochondrial Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane	Mitochondrion Peroxisome Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Mitochondrial Outer Membrane Protein-containing Complex
	Molecular Function	Phospholipase Activity Protein Binding Acylglycerol Lipase Activity	Protein Binding Identical Protein Binding
	Biological Process	Phospholipid Catabolic Process Negative Regulation Of Cell Migration Acylglycerol Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Monoacylglycerol Catabolic Process Long-term Synaptic Depression Negative Regulation Of Cold-induced Thermogenesis Regulation Of Endocannabinoid Signaling Pathway Lysobisphosphatidic Acid Metabolic Process	Mitochondrial Fission Autophagy Of Mitochondrion Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of ATP Metabolic Process Negative Regulation Of Fatty Acid Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Arachidonate production from DAG	Class I peroxisomal membrane protein import
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Platelet count ( 27863252) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 27399966 26502338)	Rheumatoid arthritis ( 30891314)
Interacting Genes		6 interacting genes: CKMT2 FIS1 PCGF2 RTP2 SCAMP4 TVP23B	30 interacting genes: A2M ABHD6 APH1A BCAP31 CREB3 DNM1L EBP ERGIC3 FAM209A FAM210B FFAR2 JAGN1 KASH5 KCNJ6 MARCHF5 MMGT1 NOS3 PIGP RNASEK SCN3B SLC10A6 SLC14A1 SLC22A1 SLC22A2 SPCS1 TBC1D15 TMEM14B TMPPE UBC VKORC1
Entrez ID		57406	51024
HPRD ID		12407	12352
Ensembl ID		ENSG00000163686	ENSG00000214253
Uniprot IDs		A0A024R323 Q9BV23	Q9Y3D6
PDB IDs			1NZN 1PC2
Enriched GO Terms of Interacting Partners?
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