SAR1A and ORMDL1

Data Source:
BioGRID (two hybrid)

		SAR1A	ORMDL1
Description		secretion associated Ras related GTPase 1A	ORMDL sphingolipid biosynthesis regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane COPII Vesicle Coat Endoplasmic Reticulum Exit Site	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane SPOTS Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protein Binding
	Biological Process	Regulation Of COPII Vesicle Coating Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Organization Membrane Organization Positive Regulation Of Protein Exit From Endoplasmic Reticulum COPII-coated Vesicle Cargo Loading	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		69 interacting genes: ADGRE2 AIG1 ALG8 APP AQP1 AQP10 AQP3 ASGR1 ATXN1 BCL2L2 C14orf180 C3orf52 CD53 CD81 CES1 CLDN19 CLDND2 CLEC7A CMTM5 COL4A5 CTSA CXCL16 EMP3 ERG28 FAM3C GJB2 GOLT1B GRM2 GYPA HMOX2 JAGN1 LAT LHFPL5 MARCHF5 MIP MOSPD3 NAT8 NRM ORMDL1 PLLP PLN PLP2 RHOT2 RMDN2 SEC22A SERP1 SLC35A1 SMIM1 SNAP47 STX7 STX8 TMEM107 TMEM109 TMEM187 TMEM218 TMEM243 TMEM254 TMEM267 TMEM42 TMEM97 TRAF3 TRAM1L1 TTPA UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5	37 interacting genes: APP AQP6 ARL13B ASGR2 COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 GPR152 HSD17B11 KCNK4 LMNA LNX1 MFSD14B PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35C2 STOM TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27
Entrez ID		56681	94101
HPRD ID		07608	15092
Ensembl ID		ENSG00000079332	ENSG00000128699
Uniprot IDs		Q5SQT9 Q9NR31	Q9P0S3
PDB IDs		2GAO
Enriched GO Terms of Interacting Partners?
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