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RNF31 and UBE2C
Data Source:
BioGRID
(pull down)
RNF31
UBE2C
Description
ring finger protein 31
ubiquitin conjugating enzyme E2 C
Image
GO Annotations
Cellular Component
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
LUBAC Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin Binding
Metal Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Polyubiquitination
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
CD40 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Linear Polyubiquitination
Positive Regulation Of Protein Targeting To Mitochondrion
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Exit From Mitosis
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Suicide behavior (
26079190
)
Height (
31562340
)
Interacting Genes
46 interacting genes:
ATN1
ATXN1
ATXN7
AZI2
CCDC24
CDC34
GFI1B
HDAC6
KIF1A
KRTAP9-2
NOS3
NR0B1
NR0B2
PITX1
PRKCA
RBCK1
SEPTIN2
SMAD3
SNRPC
SOCS3
SPATA2
STK4
TLE5
TRAF1
TRAF6
TRIM25
TSSC4
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2L3
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
UBE2T
UBE2W
VASN
VDAC1
33 interacting genes:
ANAPC11
ANAPC2
AURKA
CCNA2
CCNB1
CDC20
CKAP2
CXCR1
DTX1
ENO2
FBXO5
FZR1
GMNN
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
PTTG1
RAG1
RELA
RNF31
RNF7
TNNC1
TRIM21
TRIM28
TRIM29
TRIM72
UBA1
UBASH3B
UBE3D
Entrez ID
55072
11065
HPRD ID
11516
05717
Ensembl ID
ENSG00000092098
ENSG00000175063
Uniprot IDs
Q96EP0
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
PDB IDs
2CT7
4DBG
4JUY
4LJO
4LJP
4LJQ
4OWF
4OYJ
4OYK
4P09
4P0A
4P0B
5EDV
5LJN
5X0W
6GZY
6KC5
6KC6
6SC5
6SC6
6SC7
6SC8
6SC9
1I7K
4YII
5A31
5KHR
5L9U
Enriched GO Terms of Interacting Partners
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