PPP1CA and WWTR1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study)

		PPP1CA	WWTR1
Description		protein phosphatase 1 catalytic subunit alpha	WW domain containing transcription regulator 1
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Adherens Junction Glycogen Granule Dendritic Spine Perikaryon Extracellular Exosome PTW/PP1 Phosphatase Complex Presynapse Glutamatergic Synapse	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Nuclear Body
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase 1 Binding Phosphatase Activity Ribonucleoprotein Complex Binding Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Cell Cycle Response To Lead Ion Viral Process Dephosphorylation Lung Development Negative Regulation Of Protein Binding Circadian Regulation Of Gene Expression Peptidyl-threonine Dephosphorylation Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Branching Morphogenesis Of An Epithelial Tube Cell Division Regulation Of Canonical Wnt Signaling Pathway Peptidyl-serine Dephosphorylation Cell-cell Adhesion Beta-catenin Destruction Complex Disassembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus
Pathways		Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Circadian Clock	Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 28552196)	Height ( 31562340) Polycystic ovary syndrome ( 32289280) Preeclampsia ( 23551011)
Interacting Genes		161 interacting genes: AATK AKAP1 AKAP11 AKAP9 APAF1 AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CAV1 CCDC181 CDC5L CDH1 CEP126 CEP170 CKB CLCN2 CLOCK CLTC CNP CNST CNTN1 CREB1 CRK CSNK1E CSNK2B CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 DELEC1 DYNLT4 EED EIF2AK2 ESR1 FRMPD4 FXYD1 GLIPR1L2 GPKOW H2AX H3-3A H3C1 HEYL HSPA4 IBTK ID2 JPH3 KANK1 KCNQ1 KCTD20 KIF13A KIF18A KNL1 LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MAPT MIIP MPHOSPH10 MST1R MYO16 NCAM1 NDP NEK2 NOC2L NOM1 NONO NOP53 PAK1 PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R16B PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R27 PPP1R2B PPP1R2C PPP1R32 PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R7 PPP1R8 PPP1R9A PPP1R9B PPP2CA PPP2R5C PPP2R5E PREX1 PRKCB PRKCD PRR16 PTEN PTPN7 PYGM RANBP9 RB1 RIF1 RORC RPRD2 SFPQ SFRP1 SH3RF2 SKP1 SLC45A1 SORL1 SPRED1 STAM STAU1 SYTL2 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TUSC3 UBE2Z ULK1 VDR WBP11 WDR82 WWTR1 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827	22 interacting genes: C1orf74 DAPK1 IL16 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PPP1CA RTN4IP1 RUNX1 SLC9A3R2 SUMO3 TCP11L1 TEAD1 TEAD2 TEAD3 TEAD4 WBP2 YWHAE YWHAG YWHAZ
Entrez ID		5499	25937
HPRD ID		15942	09580
Ensembl ID		ENSG00000172531	ENSG00000018408
Uniprot IDs		A0A140VJS9 P62136	Q9GZV5
PDB IDs		3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J 4MOV 4MOY 4MP0 4XPN 5IOH 6ALZ 6CZO 6DCX 6DNO 6G0I 6G0J 6GHM 6OBN 6OBP 6OBQ 6OBR 6OBS 6OBU 6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ	5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX
Enriched GO Terms of Interacting Partners?
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