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PPP1CA and EIF2AK2
Data Source:
BioGRID
(affinity chromatography technology, pull down, enzymatic study)
HPRD
(in vivo, in vitro)
PPP1CA
EIF2AK2
Description
protein phosphatase 1 catalytic subunit alpha
eukaryotic translation initiation factor 2 alpha kinase 2
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 1 Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Glycogen Granule
Dendritic Spine
Perikaryon
Extracellular Exosome
PTW/PP1 Phosphatase Complex
Presynapse
Glutamatergic Synapse
Nucleus
Cytoplasm
Cytosol
Ribosome
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase 1 Binding
Phosphatase Activity
Ribonucleoprotein Complex Binding
Metal Ion Binding
Cadherin Binding Involved In Cell-cell Adhesion
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
RNA Binding
Double-stranded RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Regulator Activity
Identical Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Glycogen Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Glycogen Catabolic Process
Protein Dephosphorylation
Cell Cycle
Response To Lead Ion
Viral Process
Dephosphorylation
Lung Development
Negative Regulation Of Protein Binding
Circadian Regulation Of Gene Expression
Peptidyl-threonine Dephosphorylation
Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Branching Morphogenesis Of An Epithelial Tube
Cell Division
Regulation Of Canonical Wnt Signaling Pathway
Peptidyl-serine Dephosphorylation
Cell-cell Adhesion
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of MAPKK Activity
Positive Regulation Of Cytokine Production
Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Response To Virus
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Negative Regulation Of Translation
Peptidyl-tyrosine Phosphorylation
Mitigation Of Host Immune Response By Virus
Positive Regulation Of Chemokine Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Osteoblast Proliferation
Cellular Response To Amino Acid Starvation
Response To Interferon-alpha
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Hematopoietic Stem Cell Proliferation
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Triglyceride catabolism
DARPP-32 events
Downregulation of TGF-beta receptor signaling
Circadian Clock
ISG15 antiviral mechanism
Inhibition of PKR
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Fostamatinib
Diseases
GWAS
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Height (
28552196
)
Glucose homeostasis traits (
25524916
)
Platelet count (
32888494
)
Interacting Genes
161 interacting genes:
AATK
AKAP1
AKAP11
AKAP9
APAF1
AURKA
BAD
BAX
BCL2
BCL2L1
BCL2L2
BRCA1
BTBD10
C1QA
CAD
CAV1
CCDC181
CDC5L
CDH1
CEP126
CEP170
CKB
CLCN2
CLOCK
CLTC
CNP
CNST
CNTN1
CREB1
CRK
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CUL1
CXXC1
DCTN1
DCX
DEAF1
DELEC1
DYNLT4
EED
EIF2AK2
ESR1
FRMPD4
FXYD1
GLIPR1L2
GPKOW
H2AX
H3-3A
H3C1
HEYL
HSPA4
IBTK
ID2
JPH3
KANK1
KCNQ1
KCTD20
KIF13A
KIF18A
KNL1
LMTK2
LPIN2
MAFG
MAL2
MAP4K4
MAPK1
MAPK3
MAPT
MIIP
MPHOSPH10
MST1R
MYO16
NCAM1
NDP
NEK2
NOC2L
NOM1
NONO
NOP53
PAK1
PCDH7
PCNA
PHACTR1
PHACTR3
PHACTR4
PHC1
PIAS1
PIAS3
PLCL2
POLR2A
PPP1R10
PPP1R11
PPP1R13B
PPP1R13L
PPP1R15A
PPP1R15B
PPP1R16A
PPP1R16B
PPP1R18
PPP1R1B
PPP1R2
PPP1R26
PPP1R27
PPP1R2B
PPP1R2C
PPP1R32
PPP1R37
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R3E
PPP1R3G
PPP1R7
PPP1R8
PPP1R9A
PPP1R9B
PPP2CA
PPP2R5C
PPP2R5E
PREX1
PRKCB
PRKCD
PRR16
PTEN
PTPN7
PYGM
RANBP9
RB1
RIF1
RORC
RPRD2
SFPQ
SFRP1
SH3RF2
SKP1
SLC45A1
SORL1
SPRED1
STAM
STAU1
SYTL2
TOE1
TOR1AIP1
TOX4
TP53
TP53BP2
TPRN
TUSC3
UBE2Z
ULK1
VDR
WBP11
WDR82
WWTR1
YLPM1
ZBTB11
ZFYVE16
ZFYVE9
ZNF827
124 interacting genes:
ADARB1
CASP3
CASP7
CASP8
CDC42
CHUK
DHX58
DHX9
DICER1
DNAJC3
EDC4
EIF2A
EIF2S1
EIF6
ELF2
FTSJ3
H2AC20
H2AC4
HSP90AA1
HSPA1A
IKBKB
IL7R
ILF2
ILF3
JAK1
MAP3K5
MAP3K7
METAP2
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MOV10
NFKBIA
NPM1
PDGFRB
PPP1CA
PPP1CC
PPP2R5A
PRKRA
PRKRIP1
PTGES3
RAC1
STAT1
STAT3
STRBP
SUMO1
TAB2
TARBP2
THAP12
TIRAP
TOLLIP
TP53
TYK2
UBE2I
ZNF346
Entrez ID
5499
5610
HPRD ID
15942
01468
Ensembl ID
ENSG00000172531
ENSG00000055332
Uniprot IDs
A0A140VJS9
P62136
P19525
Q8IW76
PDB IDs
3E7A
3E7B
3EGG
3EGH
3HVQ
3N5U
3V4Y
4G9J
4MOV
4MOY
4MP0
4XPN
5IOH
6ALZ
6CZO
6DCX
6DNO
6G0I
6G0J
6GHM
6OBN
6OBP
6OBQ
6OBR
6OBS
6OBU
6ZEE
6ZEF
6ZEG
6ZEH
6ZEI
6ZEJ
1QU6
2A19
2A1A
3UIU
6D3K
6D3L
Enriched GO Terms of Interacting Partners
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