WWTR1 and WBP2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		WWTR1	WBP2
Description		WW domain containing transcription regulator 1	WW domain binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Nuclear Body	Chromatin Nucleus Cytoplasm
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Estrogen Receptor Binding Chromatin DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus	Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Establishment Of Protein Localization Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Progesterone Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Positive Regulation Of Histone H3-K14 Acetylation
Pathways		Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Height ( 31562340) Polycystic ovary syndrome ( 32289280) Preeclampsia ( 23551011)	Adult body size ( 32376654) Platelet count ( 32888494) Red blood cell count ( 32888494) White matter hyperintensities ( 32358547)
Interacting Genes		22 interacting genes: C1orf74 DAPK1 IL16 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PPP1CA RTN4IP1 RUNX1 SLC9A3R2 SUMO3 TCP11L1 TEAD1 TEAD2 TEAD3 TEAD4 WBP2 YWHAE YWHAG YWHAZ	54 interacting genes: ANAPC1 ANKRD13A ANKRD13D ARCN1 BAG3 CCT7 CLEC4G COPA COPB1 COPB2 COPE COPG1 CUEDC1 DDX17 EEF1B2 EPN2 ESR1 GRPEL1 H4C1 HOMER3 HUWE1 ITCH KRT18 KRT8 KRT9 LGALS8 MAGEA4 MAGI1 MYO6 NEDD4 NEDD4L PAX8 POLH RHBDD3 RNF168 RPS27A RPS3 SDHA SEPTIN3 SMAD5 TDP2 TOLLIP TOM1L2 UBA52 UBC UBE2D3 UBE2E3 UBE3A UBQLN1 UIMC1 WWP1 WWP2 WWTR1 YAP1
Entrez ID		25937	23558
HPRD ID		09580	06097
Ensembl ID		ENSG00000018408	ENSG00000132471
Uniprot IDs		Q9GZV5	A0A024R8L1 Q969T9
PDB IDs		5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX
Enriched GO Terms of Interacting Partners?
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