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WWTR1 and LATS2
Data Source:
BioGRID
(enzymatic study)
WWTR1
LATS2
Description
WW domain containing transcription regulator 1
large tumor suppressor kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Body
Spindle Pole
Nucleus
Cytosol
Centriolar Satellite
Molecular Function
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Tissue Homeostasis
Negative Regulation Of Protein Phosphorylation
Heart Process
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Protein Ubiquitination
Stem Cell Division
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Glomerulus Development
Multicellular Organism Growth
Hippo Signaling
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Mesenchymal Cell Differentiation
Cilium Assembly
Regulation Of SMAD Protein Signal Transduction
Kidney Morphogenesis
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
G1/S Transition Of Mitotic Cell Cycle
Protein Phosphorylation
Hormone-mediated Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Peptidyl-serine Phosphorylation
Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Organ Growth
Cell Division
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Nucleus
Pathways
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Physiological factors
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Signaling by Hippo
Drugs
Diseases
GWAS
Height (
31562340
)
Polycystic ovary syndrome (
32289280
)
Preeclampsia (
23551011
)
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Refractive error (
32231278
)
Interacting Genes
22 interacting genes:
C1orf74
DAPK1
IL16
LATS1
LATS2
MFHAS1
NKX2-1
PAX3
PPP1CA
RTN4IP1
RUNX1
SLC9A3R2
SUMO3
TCP11L1
TEAD1
TEAD2
TEAD3
TEAD4
WBP2
YWHAE
YWHAG
YWHAZ
67 interacting genes:
ABL1
AJUBA
AKT1
ARAF
ARNT
AURKA
AURKB
BECN1
BRAF
CBLC
CCND2
CCNE1
CD44
CDK2
CDK4
CDK6
CDKN1A
CDKN2A
CDKN2B
CDKN2C
CHEK1
CHEK2
CTNNB1
DYRK1A
EPHA2
ERBB2
EZH2
FGFR4
FHL3
FZR1
GLIS1
GLIS2
GRAP2
GRM1
HGF
HIF1A
KAT2A
KDELR2
KIF23
MAP2K3
MAP2K5
MAPK14
MDM4
MET
MOB3A
MOB3B
MOB3C
MOB4
MYC
NF2
NFIC
PDGFRA
RAF1
RASSF1
RELA
SMAD2
SNAI1
STK11
STK3
SUZ12
TAZ
TEAD2
TP53
TSC1
WWTR1
YWHAG
YWHAZ
Entrez ID
25937
26524
HPRD ID
09580
07277
Ensembl ID
ENSG00000018408
ENSG00000150457
Uniprot IDs
Q9GZV5
A0A024RDM3
Q9NRM7
PDB IDs
5N5R
5N5T
5N5W
5N75
6RHC
6RJL
6RJQ
6RP6
6SLW
6SLX
4ZRI
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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