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WWTR1
Description
WW domain containing transcription regulator 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Body
Molecular Function
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Protein Homodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Tissue Homeostasis
Negative Regulation Of Protein Phosphorylation
Heart Process
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Protein Ubiquitination
Stem Cell Division
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Glomerulus Development
Multicellular Organism Growth
Hippo Signaling
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Mesenchymal Cell Differentiation
Cilium Assembly
Regulation Of SMAD Protein Signal Transduction
Kidney Morphogenesis
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Pathways
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Physiological factors
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS
Height (
31562340
)
Polycystic ovary syndrome (
32289280
)
Preeclampsia (
23551011
)
Novel Interacting Genes
1 novel interacting genes:
PLOD2
Interacting Genes
22 interacting genes:
C1orf74
DAPK1
IL16
LATS1
LATS2
MFHAS1
NKX2-1
PAX3
PPP1CA
RTN4IP1
RUNX1
SLC9A3R2
SUMO3
TCP11L1
TEAD1
TEAD2
TEAD3
TEAD4
WBP2
YWHAE
YWHAG
YWHAZ
Entrez ID
25937
HPRD ID
09580
Ensembl ID
ENSG00000018408
Uniprot IDs
Q9GZV5
PDB IDs
5N5R
5N5T
5N5W
5N75
6RHC
6RJL
6RJQ
6RP6
6SLW
6SLX
Enriched GO Terms of Interacting Partners
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