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PPP1CA and RB1
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
PPP1CA
RB1
Description
protein phosphatase 1 catalytic subunit alpha
RB transcriptional corepressor 1
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 1 Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Glycogen Granule
Dendritic Spine
Perikaryon
Extracellular Exosome
PTW/PP1 Phosphatase Complex
Presynapse
Glutamatergic Synapse
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Spindle
Cyclin/CDK Positive Transcription Elongation Factor Complex
SWI/SNF Complex
PML Body
Rb-E2F Complex
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase 1 Binding
Phosphatase Activity
Ribonucleoprotein Complex Binding
Metal Ion Binding
Cadherin Binding Involved In Cell-cell Adhesion
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
Biological Process
Glycogen Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Glycogen Catabolic Process
Protein Dephosphorylation
Cell Cycle
Response To Lead Ion
Viral Process
Dephosphorylation
Lung Development
Negative Regulation Of Protein Binding
Circadian Regulation Of Gene Expression
Peptidyl-threonine Dephosphorylation
Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Branching Morphogenesis Of An Epithelial Tube
Cell Division
Regulation Of Canonical Wnt Signaling Pathway
Peptidyl-serine Dephosphorylation
Cell-cell Adhesion
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Tissue Homeostasis
Aortic Valve Morphogenesis
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Cell Cycle Arrest
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Viral Process
Cell Differentiation
Negative Regulation Of Cell Growth
Sister Chromatid Biorientation
Neuron Projection Development
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Cell Division
Neuron Apoptotic Process
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Cohesin Loading
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Tau-protein Kinase Activity
Positive Regulation Of Extracellular Matrix Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Triglyceride catabolism
DARPP-32 events
Downregulation of TGF-beta receptor signaling
Circadian Clock
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective translocation of RB1 mutants to the nucleus
Replication of the SARS-CoV-1 genome
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Replication of the SARS-CoV-2 genome
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Insulin human
Insulin pork
Diseases
Bladder cancer
Small cell lung cancer
Glioma
Osteosarcoma
Breast cancer
Esophageal cancer
Hepatocellular carcinoma
Chronic myeloid leukemia (CML)
GWAS
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Height (
28552196
)
Birth weight (
31043758
27680694
)
Chronic kidney disease (
26420894
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
161 interacting genes:
AATK
AKAP1
AKAP11
AKAP9
APAF1
AURKA
BAD
BAX
BCL2
BCL2L1
BCL2L2
BRCA1
BTBD10
C1QA
CAD
CAV1
CCDC181
CDC5L
CDH1
CEP126
CEP170
CKB
CLCN2
CLOCK
CLTC
CNP
CNST
CNTN1
CREB1
CRK
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CUL1
CXXC1
DCTN1
DCX
DEAF1
DELEC1
DYNLT4
EED
EIF2AK2
ESR1
FRMPD4
FXYD1
GLIPR1L2
GPKOW
H2AX
H3-3A
H3C1
HEYL
HSPA4
IBTK
ID2
JPH3
KANK1
KCNQ1
KCTD20
KIF13A
KIF18A
KNL1
LMTK2
LPIN2
MAFG
MAL2
MAP4K4
MAPK1
MAPK3
MAPT
MIIP
MPHOSPH10
MST1R
MYO16
NCAM1
NDP
NEK2
NOC2L
NOM1
NONO
NOP53
PAK1
PCDH7
PCNA
PHACTR1
PHACTR3
PHACTR4
PHC1
PIAS1
PIAS3
PLCL2
POLR2A
PPP1R10
PPP1R11
PPP1R13B
PPP1R13L
PPP1R15A
PPP1R15B
PPP1R16A
PPP1R16B
PPP1R18
PPP1R1B
PPP1R2
PPP1R26
PPP1R27
PPP1R2B
PPP1R2C
PPP1R32
PPP1R37
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R3E
PPP1R3G
PPP1R7
PPP1R8
PPP1R9A
PPP1R9B
PPP2CA
PPP2R5C
PPP2R5E
PREX1
PRKCB
PRKCD
PRR16
PTEN
PTPN7
PYGM
RANBP9
RB1
RIF1
RORC
RPRD2
SFPQ
SFRP1
SH3RF2
SKP1
SLC45A1
SORL1
SPRED1
STAM
STAU1
SYTL2
TOE1
TOR1AIP1
TOX4
TP53
TP53BP2
TPRN
TUSC3
UBE2Z
ULK1
VDR
WBP11
WDR82
WWTR1
YLPM1
ZBTB11
ZFYVE16
ZFYVE9
ZNF827
190 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAAT
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX1
CBX4
CCDC180
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CORO2A
CREG1
CTBP1
CTSV
CUX1
DGKZ
DNMT1
DVL1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FANCC
FBP1
FBP2
FOS
FRK
GALNT12
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KMT5C
L3MBTL1
LEF1
LIN54
LIN9
LMNA
MAPK1
MAPK14
MAPK3
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RASA1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SHC1
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
STX17
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TP53
TRAP1
TRIM27
TRIP11
TRMO
UBE2I
UBTF
USP4
USP7
VDR
XPA
ZBTB16
Entrez ID
5499
5925
HPRD ID
15942
01574
Ensembl ID
ENSG00000172531
ENSG00000139687
Uniprot IDs
A0A140VJS9
P62136
A0A024RDV3
P06400
PDB IDs
3E7A
3E7B
3EGG
3EGH
3HVQ
3N5U
3V4Y
4G9J
4MOV
4MOY
4MP0
4XPN
5IOH
6ALZ
6CZO
6DCX
6DNO
6G0I
6G0J
6GHM
6OBN
6OBP
6OBQ
6OBR
6OBS
6OBU
6ZEE
6ZEF
6ZEG
6ZEH
6ZEI
6ZEJ
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
Enriched GO Terms of Interacting Partners
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