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SIRT7 and H2BC21
Data Source:
BioGRID
(pull down)
SIRT7
H2BC21
Description
sirtuin 7
H2B clustered histone 21
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Nucleolus Organizer Region
Cytoplasm
Nuclear Speck
Site Of Double-strand Break
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Extracellular Exosome
Molecular Function
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
Protein-succinyllysine Desuccinylase Activity
Metal Ion Binding
Protein-glutaryllysine Deglutarylase Activity
NAD+ Binding
NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
Protein-propionyllysine Depropionylase Activity
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Regulation Of Gluconeogenesis
DNA Repair
Regulation Of DNA Repair
Protein Deacetylation
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Transcription Involved In Exit From Mitosis
Homologous Chromosome Pairing At Meiosis
RRNA Transcription
Negative Regulation Of Transposition
Regulation Of Mitochondrion Organization
Histone Modification
Negative Regulation Of Protein Ubiquitination
Peptidyl-lysine Desuccinylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Protein Export From Nucleus
Protein Deglutarylation
Peptidyl-lysine Deglutarylation
R-loop Disassembly
Histone H3 Deacetylation
Histone H4 Deacetylation
Protein Depropionylation
Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Histone Glutamine Methylation
Positive Regulation Of RRNA Processing
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Interacting Genes
12 interacting genes:
APP
DDB1
FBL
H2AC20
H2BC21
H3C1
H4C1
MAGED1
POLR1E
RRP9
USP7
WDR77
77 interacting genes:
AIRE
AKT1
ANP32A
AP2M1
ARID1B
ATF2
ATXN7L3
BARD1
BRD2
BRD7
CDK9
CREBBP
DNMT3L
DYRK2
EP300
GADD45A
GATAD2A
GATAD2B
GZMA
H2AC20
HDAC2
HIPK2
HIRA
HIRIP3
HSPD1
IL33
IL7R
KAT2A
KAT2B
KPNA1
LALBA
LOX
MAP4K4
MDM2
MSL1
MSL2
NAP1L4
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT6
PTMA
RAG1
RCC1
RNF168
RNF20
RNF8
RPS6KA5
SAP30
SART3
SIRT7
SMARCA4
SMU1
SPANXN2
SSRP1
STK38
STK4
TAF1A
TAF1B
TBL1X
TBL1XR1
TCF20
TGM2
TNPO1
TRAF6
TSPY1
UBC
UBE2A
USP12
USP15
USP22
USP46
USP49
USP8
VRK1
Entrez ID
51547
8349
HPRD ID
12094
03494
Ensembl ID
ENSG00000187531
ENSG00000184678
Uniprot IDs
Q9NRC8
Q16778
PDB IDs
5IQZ
6G0S
4NFT
6A7U
6KBB
6M4D
6M4G
6M4H
Enriched GO Terms of Interacting Partners
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