SIRT7 and WDR77

Data Source:
BioGRID (pull down, enzymatic study)

		SIRT7	WDR77
Description		sirtuin 7	WD repeat domain 77
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Nucleolus Organizer Region Cytoplasm Nuclear Speck Site Of Double-strand Break	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Pole Plasm
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Deacetylase Activity NAD-dependent Protein Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific) Protein-propionyllysine Depropionylase Activity	Protein Binding Methyl-CpG Binding Nuclear Receptor Coactivator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Protein Deacetylation Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription Involved In Exit From Mitosis Homologous Chromosome Pairing At Meiosis RRNA Transcription Negative Regulation Of Transposition Regulation Of Mitochondrion Organization Histone Modification Negative Regulation Of Protein Ubiquitination Peptidyl-lysine Desuccinylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Export From Nucleus Protein Deglutarylation Peptidyl-lysine Deglutarylation R-loop Disassembly Histone H3 Deacetylation Histone H4 Deacetylation Protein Depropionylation Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Histone Glutamine Methylation Positive Regulation Of RRNA Processing Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Pole Plasm Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription, DNA-templated Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways			snRNP Assembly RMTs methylate histone arginines
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: APP DDB1 FBL H2AC20 H2BC21 H3C1 H4C1 MAGED1 POLR1E RRP9 USP7 WDR77	44 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 RIOK1 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZMYND19 ZNF207
Entrez ID		51547	79084
HPRD ID		12094	14387
Ensembl ID		ENSG00000187531	ENSG00000116455
Uniprot IDs		Q9NRC8	A0A024R0H7 Q9BQA1
PDB IDs		5IQZ 6G0S	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UXX 6UXY 6V0N 6V0O
Enriched GO Terms of Interacting Partners?
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